Evidence map›Paper›PMID 34685498›Full record

ReviewCells2021

Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases.

Valentina Tedeschi, Daniele La Russa, Cristina Franco, Antonio Vinciguerra, Diana Amantea, Agnese Secondo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Variation inCirculation research · 2026
    Article
  2. Article
  3. Inter-Organellar CaCells · 2025
    Review
  4. SOCE as a regulator of neuronal activity.The Journal of physiology · 2024
    Review
  5. Article
  6. Article
  7. Localisation of Intracellular Signals and Responses during Phagocytosis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Valentina TedeschiDepartment of Neuroscience, Division of Pharmacology, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
Daniele La RussaSection of Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-1887-2854
Cristina FrancoDepartment of Science and Technology-DST, Division of Pharmacology, University of Sannio, 82100 Benevento, Italy.
Antonio VinciguerraDepartment of Neuroscience, Division of Pharmacology, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.
Diana AmanteaSection of Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-7513-3495
Agnese SecondoDepartment of Neuroscience, Division of Pharmacology, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", 80131 Napoli, Italy.ORCID 0000-0001-5054-4098
University of Calabria · ITUniversity of Naples Federico II · ITFederico II University Hospital · ITUniversity of Sannio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca

Indexed as

AnimalsCalciumCalcium ChannelsCell MembraneHumansMembrane ProteinsNeoplasm ProteinsNeurodegenerative DiseasesStromal Interaction Molecule 1CalciumCalcium ChannelsMembrane ProteinsNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1amyotrophic lateral sclerosis (ALS)Ca2+ homeostasisCa2+-storing organellesendoplasmic reticulum (ER)lysosomes

Identifiers

PMID34685498
PMCPMC8533710
OpenAlexW3202334541

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.