Evidence map›Paper›PMID 34685515›Full record

ReviewCells2021

How Viruses Hijack and Modify the Secretory Transport Pathway.

Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Nonlytic Egress and Transmission in the Virus World.Annual review of biochemistry · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. The effect of COVID-19 and sex differences on natural killer cell cytotoxicity.Frontiers in cellular and infection microbiology · 2025
    Article
  16. Review
  17. Host Subcellular Organelles: Targets of Viral Manipulation.International journal of molecular sciences · 2024
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Zubaida HassanDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Nilima Dinesh KumarDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.
Fulvio ReggioriDepartment of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands.ORCID 0000-0003-2652-2686
Gulfaraz KhanDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.ORCID 0000-0001-6836-1783
United Arab Emirates University · AEUniversity Medical Center Groningen · NL

Funding

Al Jalila Foundation 21M132ALW Open Programme (ALWOP.310), ENW KLEIN-1 (OCENW.KLEIN.118) and ZonMW TOP (91217002)Marie Skłodowska-Curie Cofund grant No 713660United Arab Emirates University 31R0135; 31R246
6 · The paper itself

Abstract

Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to

Indexed as

Biological TransportCell MembraneEndoplasmic ReticulumGolgi ApparatusHumansSecretory PathwayVirusesendoplasmic reticulumGolgiintracellular traffickingmembrane rearrangementsplasma membranevesiclesviruses

Identifiers

PMID34685515
PMCPMC8534161
OpenAlexW3203263628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.