ReviewCells2021
The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth.
Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036003 (Recombinant Human Growth Hormone), which is not on this map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR): a Pilot, Randomized Placebo-controlled Trial
Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Global trends in recombinant human growth hormone for the treatment of idiopathic short stature: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Exploring the Therapeutic Potential of Targeting GH and IGF-1 in the Management of Obesity: Insights from the Interplay between These Hormones and Metabolism.International journal of molecular sciences · 2023Pooled it
- New insights on the cardiovascular effects of IGF-1.Frontiers in endocrinology · 2023Pooled it
- Trial
- The effects of nanocurcumin on immune-related factors in the ankylosing spondylitis patients: a double-blind, randomized, placebo-controlled clinical trial.Molecular biology reports · 2025Trial
- Serum insulin-like growth factor-1 and its association with epilepsy risk and cognitive function.Acta epileptologica · 2026Article
- Beyond insulin-like growth factor-1 (IGF-1) normalization: portal insulin and hepatic growth hormone (GH) sensitivity across metabolic disease.Archives of endocrinology and metabolism · 2026Review
- Bovine appeasing pheromone mitigates long-distance transport stress to improve health and growth performance in beef cattle.Tropical animal health and production · 2026Article
- Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026Review
- Comparative Effects of Processed Soybean Protein Sources on Growth, Serum Immune and Endocrine Profiles, and Colonic Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- Examining the role of insulin-like growth factor 1 in the pathophysiology of carpal tunnel syndrome: a Mendelian randomization study.International journal of epidemiology · 2026Article
- Hypothalamus-Peripheral Organ Crosstalk in Energy Metabolism: A Bidirectional Regulatory Network.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- The Osteoimmunologic Basis of Biologic and Bioengineered Therapies in Osteoarthritis.Biomedicines · 2026Review
- Association of leptin and insulin-like growth factor-1 gene polymorphisms with milk production and reproductive traits in Indonesian Friesian Holstein cattle.Veterinary world · 2026Article
- Primary peripheral nerve repair: A systematic review of sutures, fibrin glue, and biologic-augmented approaches.JPRAS open · 2026Review
- Remembrance of things past: Towards a life-course biology of aging.PLoS biology · 2026Article
- Genotypic and expression analysis of the insulin- like growth factor (IGF-1) gene across growth stages in indigenous sheep.Molecular biology reports · 2026Article
- Nutritional and managerial interventions on growth performance, nutrient transport-related genes and behavioral responses in heats stressed broiler chickens.Veterinary and animal science · 2026Article
- 3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network.bioRxiv : the preprint server for biology · 2026Article
- 3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network.Briefings in bioinformatics · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master regulator of somatic development and involved, directly and indirectly, in carbohydrate and lipid metabolism via complex, yet well-defined, signaling pathways. GH production from the pituitary gland is primarily regulated by the counter-regulatory effects of the hypothalamic GHRH and SST hormones. The role of IGF-1 feedback regulation in GH production has been demonstrated by pharmacologic interventions and in genetically modified mouse models. In the present review, we discuss the role of IGF-1 in the regulation of the GH-axis as it controls somatic growth and metabolic homeostasis. We present genetically modified mouse models that maintain the integrity of the GH/GHRH-axis with the single exception of IGF-1 receptor (IGF-1R) deficiency in the hypothalamic GHRH neurons and somatotroph that reveals a novel mechanism controlling adipose tissues physiology and energy expenditure.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.