Evidence map›Paper›PMID 34685684›Full record

ArticleCells2021

Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association.

Deokhwan Kim, Hyunji Moon, Hyeokjin Cho, Chanhyuk Min, Byeongjin Moon, Susumin Yang, Juyeon Lee, Sang-Ah Lee, Hyunjin Park, Dae-Hee Lee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. After cell death: the molecular machinery of efferocytosis.Experimental & molecular medicine · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Deokhwan KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-6900-3870
Hyunji MoonSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Hyeokjin ChoSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Chanhyuk MinSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0001-8898-7898
Byeongjin MoonSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0001-9424-3270
Susumin YangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-1634-5527
Juyeon LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Sang-Ah LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-0860-3274
Hyunjin ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dae-Hee LeeDepartment of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25456, Korea.
Dongtak JeongDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University ERICA Campus, Ansan 15588, Korea.
Gwangrog LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-1720-8524
Daeho ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-2824-490X
Gwangju Institute of Science and Technology · KRGangneung–Wonju National University · KRHanyang University · KR

Funding

National Research Foundation of Korea 2019R1A2C1006480National Research Foundation of Korea 2019R1A4A1028802
6 · The paper itself

Abstract

Swift and continuous phagocytosis of apoptotic cells can be achieved by modulation of calcium flux in phagocytes. However, the molecular mechanism by which apoptotic cells modulate calcium flux in phagocytes is incompletely understood. Here, using biophysical, biochemical, pharmaceutical, and genetic approaches, we show that apoptotic cells induced the Orai1-STIM1 interaction, leading to store-operated calcium entry (SOCE) in phagocytes through the Mertk-phospholipase C (PLC) γ1-inositol 1,4,5-triphosphate receptor (IP

Indexed as

ApoptosisAnimalsCalciumc-Mer Tyrosine KinaseEndocytosisInositol 1,4,5-Trisphosphate ReceptorsMiceMice, Inbred C57BLNIH 3T3 CellsORAI1 ProteinPhagocytesPhospholipase C gammaProtein BindingRAW 264.7 CellsSignal TransductionStromal Interaction Molecule 1Calciumc-Mer Tyrosine KinaseInositol 1,4,5-Trisphosphate ReceptorsMertk protein, mouseORAI1 ProteinPhospholipase C gammaStromal Interaction Molecule 1calcium fluxefferocytosisinteractionMertkOrai1SOCESTIM1

Identifiers

PMID34685684
PMCPMC8534458
OpenAlexW3207339641

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.