Evidence map›Paper›PMID 34685759›Full record

ArticleCells2021

Foxd4l1.1 Negatively Regulates Chordin Transcription in Neuroectoderm of

Vijay Kumar, Ravi Shankar Goutam, Zobia Umair, Soochul Park, Unjoo Lee, Jaebong Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Organizer and Its Signaling in Embryonic Development.Journal of developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vijay KumarDepartment of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Korea.ORCID 0000-0003-1518-196X
Ravi Shankar GoutamDepartment of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Korea.ORCID 0000-0002-5855-0238
Zobia UmairDepartment of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Soochul ParkDepartment of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea.
Unjoo LeeDepartment of Electrical Engineering, Hallym University, Chuncheon 24252, Korea.
Jaebong KimDepartment of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Hallym University · KRGachon University · KRSookmyung Women's University · KR

Funding

National Research Foundation of Korea 2016R1D1A1B02008770, 2016M3A9B8914057, 2018M3C7A1056285, and 2021R1A4A1027355
6 · The paper itself

Abstract

Inhibition of the bone morphogenetic proteins (BMPs) is the primary step toward neuroectoderm formation in vertebrates. In this process, the Spemann organizer of the dorsal mesoderm plays a decisive role by secreting several extracellular BMP inhibitors such as Chordin (Chrd). Chrd physically interacts with BMP proteins and inhibits BMP signaling, which triggers the expression of neural-specific transcription factors (TFs), including Foxd4l1.1. Thus, Chrd induces in a BMP-inhibited manner and promotes neuroectoderm formation. However, the regulatory feedback mechanism of Foxd4l1.1 on mesodermal genes expression during germ-layer specification has not been fully elucidated. In this study, we investigated the regulatory mechanism of Foxd4l1.1 on

Indexed as

Gene Expression Regulation, DevelopmentalTranscription, GeneticActivinsAnimalsDNA-Binding ProteinsEctodermEmbryo, NonmammalianGastrulaGenes, ReporterGlycoproteinsIntercellular Signaling Peptides and ProteinsMesodermPromoter Regions, GeneticProtein BindingProtein DomainsResponse ElementsActivinschordinDNA-Binding Proteinsfoxd4l1.1 protein, XenopusGlycoproteinsIntercellular Signaling Peptides and ProteinsSmad ProteinsXenopus ProteinsChrdFoxd4l1.1neural repressorSmad2Smad3transcription regulationXenopus

Identifiers

PMID34685759
PMCPMC8534798
OpenAlexW3206488292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.