ArticleNature communications2021
The flashfm approach for fine-mapping multiple quantitative traits.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.Nature communications · 2023Pooled it
- Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping.Nature communications · 2026Article
- Genetics of skeletal proportions across two different populations.American journal of human genetics · 2026Article
- Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci.Human molecular genetics · 2026Article
- Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model.Nature genetics · 2026Article
- Towards improved fine-mapping of candidate causal variants.Nature reviews. Genetics · 2025Review
- Improved genetic discovery and fine-mapping resolution through multivariate latent factor analysis of high-dimensional traits.Cell genomics · 2025Article
- The goldmine of GWAS summary statistics: a systematic review of methods and tools.BioData mining · 2024Article
- Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.Nature genetics · 2024Article
- A cross-disease, pleiotropy-driven approach for therapeutic target prioritization and evaluation.Cell reports methods · 2024Article
- A Bayesian fine-mapping model using a continuous global-local shrinkage prior with applications in prostate cancer analysis.American journal of human genetics · 2024Article
- Integration of expression QTLs with fine mapping via SuSiE.PLoS genetics · 2024Article
- Leveraging information between multiple population groups and traits improves fine-mapping resolution.Nature communications · 2023Article
- Shared components of heritability across genetically correlated traits.American journal of human genetics · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Joint fine-mapping that leverages information between quantitative traits could improve accuracy and resolution over single-trait fine-mapping. Using summary statistics, flashfm (flexible and shared information fine-mapping) fine-maps signals for multiple traits, allowing for missing trait measurements and use of related individuals. In a Bayesian framework, prior model probabilities are formulated to favour model combinations that share causal variants to capitalise on information between traits. Simulation studies demonstrate that both approaches produce broadly equivalent results when traits have no shared causal variants. When traits share at least one causal variant, flashfm reduces the number of potential causal variants by 30% compared with single-trait fine-mapping. In a Ugandan cohort with 33 cardiometabolic traits, flashfm gave a 20% reduction in the total number of potential causal variants from single-trait fine-mapping. Here we show flashfm is computationally efficient and can easily be deployed across publicly available summary statistics for signals in up to six traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.