Evidence map›Paper›PMID 34689705›Full record

ArticleTissue barriers2022

ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing.

Laura González-González, Helios Gallego-Gutiérrez, Dolores Martin-Tapia, José Everardo Avelino-Cruz, Christian Hernández-Guzmán, Sergio Israel Rangel-Guerrero, Luis Marat Alvarez-Salas, Erika Garay, Bibiana Chávez-Munguía, María Concepción Gutiérrez-Ruiz and 3 more

Open access · greenAbstract read
In one paragraph

Article in Tissue barriers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Laura González-GonzálezDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Helios Gallego-GutiérrezDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.ORCID 0000-0003-0369-9083
Dolores Martin-TapiaDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
José Everardo Avelino-CruzLaboratory of Molecular Cardiology, Institute of Physiology, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Christian Hernández-GuzmánDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.ORCID 0000-0003-4372-2073
Sergio Israel Rangel-GuerreroDepartment of Genetics and Molecular Biology, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Luis Marat Alvarez-SalasDepartment of Genetics and Molecular Biology, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.ORCID 0000-0002-3646-3723
Erika GarayDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Bibiana Chávez-MunguíaDepartment of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
María Concepción Gutiérrez-RuizDepartment of Health Sciences, Autonomous Metropolitan University- Iztapalapa (UAM-I), Mexico City, Mexico; Laboratory of Experimental Medicine, Unit of Translational Medicine, Institute of Biomedical Research, Unam, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
Dinorah Hernández-MelchorDepartment of Toxicology, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Esther López-BayghenDepartment of Toxicology, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Lorenza González-MariscalDepartment of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXBenemérita Universidad Autónoma de Puebla · MXUniversidad Autónoma Metropolitana · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ZO-2 is a peripheral

Indexed as

AMP-Activated Protein KinasesFatty LiverAnimalsHippo Signaling PathwayHypertrophyRatsRats, ZuckerTight Junction ProteinsZonula Occludens-2 ProteinAMP-Activated Protein KinasesTight Junction ProteinsTjp2 protein, ratZonula Occludens-2 ProteinHippo pathwayhypertrophyliver steatosismetforminSp1ZO-2

Identifiers

PMID34689705
PMCPMC9067463
OpenAlexW3210440546

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.