Evidence map›Paper›PMID 34689834›Full record

ArticleAnimal microbiome2021

Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs.

Yuliaxis Ramayo-Caldas, Laura M Zingaretti, David Pérez-Pascual, Pamela A Alexandre, Antonio Reverter, Antoni Dalmau, Raquel Quintanilla, Maria Ballester

Open access · goldAbstract read
In one paragraph

Article in Animal microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  12. Copy Number Variation onMicrobiology spectrum · 2023
    Article
  13. On the holobiont 'predictome' of immunocompetence in pigs.Genetics, selection, evolution : GSE · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yuliaxis Ramayo-Caldas *Animal Breeding and Genetics Program, IRTA, Torre Marimón, 08140, Caldes de Montbui, Barcelona, Spain. yuliaxis.ramayo@irta.cat.ORCID http://orcid.org/0000-0002-8142-0159
Laura M Zingaretti *Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
David Pérez-PascualUnité de Génétique des Biofilms, Institut Pasteur, UMR CNRS2001, Paris, France.
Pamela A AlexandreCSIRO Agriculture and Food, St. Lucia, Brisbane, QLD, 4067, Australia.
Antonio ReverterCSIRO Agriculture and Food, St. Lucia, Brisbane, QLD, 4067, Australia.
Antoni DalmauAnimal Welfare Subprogram, IRTA, 17121, Monells, Girona, Spain.
Raquel QuintanillaAnimal Breeding and Genetics Program, IRTA, Torre Marimón, 08140, Caldes de Montbui, Barcelona, Spain.
Maria BallesterAnimal Breeding and Genetics Program, IRTA, Torre Marimón, 08140, Caldes de Montbui, Barcelona, Spain. maria.ballester@irta.cat.
Institute of Agrifood Research and Technology · ESCommonwealth Scientific and Industrial Research Organisation · AUCentre National de la Recherche Scientifique · FRUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gut microbiota influences host performance playing a relevant role in homeostasis and function of the immune system. The aim of the present work was to identify microbial signatures linked to immunity traits and to characterize the contribution of host-genome and gut microbiota to the immunocompetence in healthy pigs.

resultsTo achieve this goal, we undertook a combination of network, mixed model and microbial-wide association studies (MWAS) for 21 immunity traits and the relative abundance of gut bacterial communities in 389 pigs genotyped for 70K SNPs. The heritability (h

conclusionsOverall, our findings reveal an important connection between gut microbiota composition and immunity traits in pigs, and highlight the need to consider both sources of information, host genome and microbial levels, to accurately characterize immunocompetence in pigs.

Identifiers

PMID34689834
PMCPMC8543910
OpenAlexW3208638168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.