Evidence map›Paper›PMID 34696610›Full record

ArticleInternational journal of immunopathology and pharmacology

Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF-β1/SMAD factors.

Hager S Taha, Enas M Moustafa, Fatma Sm Moawed, Marwa Ga Hegazy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hager S TahaBiochemistry Department, Faculty of Science, 247928Ain Shams University, Cairo, Egypt.
Enas M MoustafaRadiation Biology Department, National Center for Radiation Research & Technology (NCRRT), 68892Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID https://orcid.org/0000-0003-0484-5759
Fatma Sm MoawedHealth Radiation Research Department, National Center for Radiation Research & Technology (NCRRT), 68892Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID https://orcid.org/0000-0002-5792-0815
Marwa Ga HegazyBiochemistry Department, Faculty of Science, 247928Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-6949-3304
Ain Shams University · EGEgyptian Atomic Energy Authority · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveLiving organisms respond to physical, chemical, and biological threats with a potent inflammatory response which alters organ cell signaling and leads to dysfunction. We evaluated the therapeutic effect of bone marrow-based mesenchymal stromal cell (BM-MSC) transplanted in rats to preserve tissue integrity and to restore homeostasis and function in the pancreatitis experimental pattern.

methodsThis study involved 40 adult male Wister rats. Repeated L-arginine injections caused chronic pancreatitis (CP), leading to the development of pancreatic damage and shifting the intracellular signaling pathways. Rats were then infused with BM-MSC labeled with PKH26 fluorescent linker dye for 12 weeks.

resultsCell-surface indicators of BM-MSCs such as CD 90 and CD29 were expressed with the lack of CD34 expression. BM-MSC treatment considerably improved the alterations induced in a series of inflammatory markers, including IL-18, TNF-α, CRP, PGE2, and MCP-1. Furthermore, improvement was found in digestive enzymes and lipid profile with amelioration in myeloperoxidase activity. BM-MSC treatment also regulated the (TGF-/p-38MPAK/SMAD2/3) signaling factors that enhances repair of damaged pancreatic tissue, confirmed by reversed alteration of histopathological examination.

conclusionour results further bring to light the promise of cell transplant therapy for chronic pancreatitis.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAmylasesAnimalsArginineC-Reactive ProteinCytokinesDinoprostoneLipaseLipid MetabolismMalep38 Mitogen-Activated Protein KinasesPancreasPancreatitis, ChronicRatsRats, WistarAmylasesArginineC-Reactive ProteinCytokinesDinoprostoneLipasep38 Mitogen-Activated Protein KinasesSmad2 ProteinSmad2 protein, ratSmad3 ProteinSmad3 protein, ratChronic pancreatitisMPAKSMADstromal cellsTGF-β

Identifiers

PMID34696610
PMCPMC8552371
OpenAlexW3209984182

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.