Evidence map›Paper›PMID 34697657›Full record

Trial reportClinical oral investigations2022

The antibacterial effect and the incidence of post-operative pain after the application of nano-based intracanal medications during endodontic retreatment: a randomized controlled clinical trial.

Mahmoud M Fahim, Shehab Eldin Mohamed Saber, Walid F Elkhatib, Mohamed Mokhtar Nagy, Edgar Schafer

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06533215 (Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06533215 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis

TypeinterventionalSponsorTanta UniversityRan2024 to 2025Enrolled30ConditionsEnterococcus Faecalis Infection, Endodontically Treated Teeth, Endodontic DiseaseArmsantimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases.
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mahmoud M FahimDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Shehab Eldin Mohamed SaberDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. Shehabeldin.saber@bue.edu.eg.
Walid F ElkhatibDepartment of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Mohamed Mokhtar NagyDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Edgar SchaferCentral Interdisciplinary Ambulance in the School of Dentistry, University of Münster, Münster, Germany.
Ain Shams University · EGUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis clinical trial aimed to evaluate the effect of nano-silver and nano-calcium hydroxide intracanal medicaments (ICM) during retreatment regarding their antibacterial effect and their effect on post-operative pain and flare-ups. MATERIALS AND

methodsSixty-nine patients scheduled for endodontic retreatment were included in this randomized clinical trial and randomly allocated to 3 equal groups (n = 23) according to the type of ICM used. The first microbial sampling (S1) representing the original microbiota was obtained after the removal of the old canal filling. After chemo-mechanical debridement, another sample (S2) was obtained representing the microbial state before ICM application. Patients were randomly allocated to receive either nano-silver (nano-Ag), nano-calcium hydroxide (nano-CH), or calcium hydroxide (CH) as ICM. Patients rated their pain pre-operatively and then after 6, 12, 24, 48, and 72 h. During the second visit (7 days later), the last microbial sample (S3) was obtained after removal of the ICM. Reduction of total bacterial and total E. faecalis counts and the biofilm-forming capability of the existing microbiota were determined.

resultsResults showed reduction in total bacterial count, total E. faecalis count and the biofilm-forming,capability of the existing microbiota after chemo-mechanical debridement (S1-S2) and after the application of ICM (S3-S2). However, the reduction after cleaning and shaping was significantly more pronounced (p < 0.001) compared to the effect of ICM application, with no difference between the 3 ICM (p > 0.05). Post-operative pain was significantly reduced at the 48- and 72-h intervals after the application of nano-Ag and nano-CH only (p < 0.001), with no significant difference between these two ICM (p > 0.05). The incidence of flare-ups in all groups was similar (p > 0.05).

conclusionsThe antibacterial effect of the nano-Ag and nano-CH was equivalent to that of CH, but they contributed to better pain control. CLINICAL RELEVANCE: Nanoparticles may have a positive impact on post-endodontic pain.

Indexed as

Periapical PeriodontitisRoot Canal IrrigantsAnti-Bacterial AgentsCalcium HydroxideChlorhexidineDental Pulp CavityHumansIncidencePostoperative PainAnti-Bacterial AgentsCalcium HydroxideChlorhexidineRoot Canal IrrigantsBacterial reductionCalcium hydroxideEndodontic retreatmentFlare-upsIntracanal medicationsNano-calcium hydroxideNano-silverPost-operative pain

Identifiers

PMID34697657
OpenAlexW3208636266

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.