Evidence map›Paper›PMID 34704166›Full record

ArticleJournal of assisted reproduction and genetics2021

Male factor infertility and placental pathology in singleton live births conceived with in vitro fertilization.

Roisin Mortimer, K James, C L Bormann, A L Harris, J Yeh, T L Toth, I Souter, D J Roberts, C R Sacha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Roisin MortimerDepartment of OB/GYN, Massachusetts General Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. rmortimer@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-6409-892X
K JamesCenter for Outcomes Research, Department of OB/GYN, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
C L BormannMassachusetts General Hospital Fertility Center and Harvard Medical School, Boston, MA, USA.
A L HarrisDepartment of Women's Health, Wright Patterson Air Force Base, Wright Patterson AFB, Dayton, OH, USA.
J YehDivision of Reprod Endo & Infertil, UMass Medical, Worcester, MA, USA.
T L TothBoston IVF, Department of OB/GYN, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
I SouterMassachusetts General Hospital Fertility Center and Harvard Medical School, Boston, MA, USA.
D J RobertsDepartment of Pathology, Harvard Medical School and Massachusetts General, Boston Hospital, Boston, MA, USA.
C R SachaMassachusetts General Hospital Fertility Center and Harvard Medical School, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USUMass Memorial Health Care · USWright State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe sought to determine whether pregnancies conceived in those with male factor infertility have unique placental pathology profiles compared to those undergoing infertility treatments for other indications.

methodsThis was a retrospective cohort study of placental pathology from 464 live births conceived from autologous fresh IVF cycles at an academic fertility center from 2004 to 2017. Placental pathology was compared between live births arising from patients with male factor infertility alone and those with another infertility diagnosis. Placental outcomes were compared with parametric or non-parametric tests; logistic regression was performed to account for potential confounders.

resultsCompared to cycles performed for a non-male factor diagnosis, male factor infertility cycles had a higher mean paternal age (38.2 years vs. 36.5 years, p < 0.001), a higher female mean BMI (24.3 vs. 23.3 kg/m

conclusionMale factor infertility is not associated with significantly different placental pathology compared to other infertility diagnoses.

Indexed as

AdultBirth WeightEmbryo TransferFemaleFertilizationFertilization in VitroHumansInfertility, MaleLive BirthMaleMenPlacentaPlacenta DiseasesPregnancyPregnancy RateRetrospective StudiesICSIIVFMale factor infertilityPathologyPlacenta

Identifiers

PMID34704166
PMCPMC8666390
OpenAlexW3209401611

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.