Metformin × cardiovascular events

SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2021

Glucagon-like Peptide-1 Receptor Agonists and Cardioprotective Benefit in Patients with Type 2 Diabetes Without Baseline Metformin: A Systematic Review and Update Meta-analysis.

Augusto Lavalle-Cobo et al.PubMed ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer cardiovascular events

−14%−21% to −6%

Bigger than 3 in 10 for cardiovascular events

As reported

HR 0.86, 95% CI 0.79–0.94

One number in the abstract

the abstract, start to end

reduction in MACE incidence (HR: 0.86, 95% confidence interval:

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.860.79–0.94
MetforminCardiovascular events
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