Evidence map›Paper›PMID 34706928›Full record

ArticleJournal of epidemiology and community health2022

Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.

Molly Scannell Bryan, Temidayo Ogundiran, Oladosu Ojengbede, Wei Zheng, William Blot, Susan Domcheck, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Olufunmilayo I Olopade and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of epidemiology and community health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Molly Scannell BryanInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0003-1030-3155
Temidayo OgundiranDepartment of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria, Ibadan, Nigeria.
Oladosu OjengbedeCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-1226-070X
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Susan DomcheckDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anselm HennisChronic Disease Research Centre, Tropical Medicine Research Institute, The University of the West Indies, Bridgetown, Barbados.
Barbara NemesureDepartment of Preventative Medicine, State University of New York at Stony Brook, Stony Brook, New York, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland, USA.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA dhuo@uchicago.edu.
University of Ibadan · NGVanderbilt University · USChicago Department of Public Health · USNational Cancer Institute · USState University of New York · USUniversity of Chicago · USUniversity of Illinois Chicago · USUniversity of Pennsylvania · USUniversity of the West Indies · BB

Funding

Novel Markers for Disease Outcome in Breast CancerZIABC010887 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.5M
UIC CANCER PREVENTION &CONTROL RESEARCH TRAINING GRANTR25CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FITZGIBBON, MARIAN L. · 1992 to 2017
$8.2M
Polygenic Risk Prediction of Breast Cancer for Women of African DescentR01CA228198 · NCI · UNIVERSITY OF CHICAGO · PI Dezheng Huo · 2018 to 2026
$3.9M
Cancer Health Equity Career Development ProgramT32CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Marian L. Fitzgibbon · 2018 to 2026
$3.0M
Genome-wide association study of breast cancer in the African DiasporaR01CA142996 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2010 to 2012
$1.5M
NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA228198NCI NIH HHS R25 CA057699NCI NIH HHS T32 CA057699
6 · The paper itself

Abstract

introductionMany diseases of adulthood are associated with a woman's age at menarche. Genetic variation affects age at menarche, but it remains unclear whether in women of African ancestry the timing of menarche is regulated by genetic variants that were identified in predominantly European and East Asian populations.

methodsWe explored the genetic architecture of age at menarche in 3145 women of African ancestry who live in the USA, Barbados and Nigeria. We undertook a genome-wide association study, and evaluated the performance of previously identified variants.

resultsOne variant was associated with age at menarche, a deletion at chromosome 2 (chr2:207216165) (p=1.14×10 DISCUSSION: This study suggests that in women of African ancestry the genetic drivers of age at menarche may differ from those identified in populations of non-African ancestry, and that these differences are more pronounced in women living in Nigeria, although some associated trait loci may be shared across populations. This highlights the need for well-powered ancestry-specific genetic studies to fully characterise the genetic influences of age at menarche.

Indexed as

Genome-Wide Association StudyMenarcheAdultAsian PeopleBlack PeopleFemaleHumansPolymorphism, Single Nucleotideepidemiologygenetic epidemreproductive health

Identifiers

PMID34706928
PMCPMC9011920
OpenAlexW3208560920

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.