Evidence map›Paper›PMID 34708739›Full record

ReviewIndian journal of ophthalmology2021

Inflammatory mediators in diabetic retinopathy: Deriving clinicopathological correlations for potential targeted therapy.

Abhishek Sheemar, Deepak Soni, Brijesh Takkar, Soumyava Basu, Pradeep Venkatesh

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Abhishek SheemarDepartment of Ophthalmology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Deepak SoniDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Brijesh TakkarSmt. Kanuri Santhamma Center for Vitreoretinal Diseases; Indian Health Outcomes, Public Health and Economics Research (IHOPE) Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Soumyava BasuUveitis Service, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Pradeep VenkateshDr.R.P.Centre for Ophthalmic Sciences, All India Institute of Medical Science, New Delhi, India.
All India Institute of Medical Sciences Jodhpur · INL V Prasad Eye Institute · INAll India Institute of Medical Sciences Bhopal · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of inflammation in diabetic retinopathy (DR) is well-established and dysregulation of a large number of inflammatory mediators is known. These include cytokines, chemokines, growth factors, mediators of proteogenesis, and pro-apoptotic molecules. This para-inflammation as a response is not directed to a particular pathogen or antigen but is rather directed toward the by-products of the diabetic milieu. The inflammatory mediators take part in cascades that result in cellular level responses like neurodegeneration, pericyte loss, leakage, capillary drop out, neovascularization, etc. There are multiple overlaps between the inflammatory pathways occurring within the diabetic retina due to a large number of mediators, their varied sources, and cross-interactions. This makes understanding the role of inflammation in clinical manifestations of DR difficult. Currently, mediator-based therapy for DR is being evaluated for interventions that target a specific step of the inflammatory cascade. We reviewed the role of inflammation in DR and derived a simplified clinicopathological correlation between the sources and stimuli of inflammation, the inflammatory mediators and pathways, and the clinical manifestations of DR. By doing so, we deliberate mediator-specific therapy for DR. The cross-interactions between inflammatory mediators and the molecular cycles influencing the inflammatory cascades are crucial challenges to such an approach. Future research should be directed to assess the feasibility of the pathology-based therapy for DR.

Indexed as

Diabetes MellitusDiabetic RetinopathyCytokinesHumansInflammationInflammation MediatorsRetinaCytokinesInflammation MediatorsComplications of diabetes mellitusdiabetic retinopathyinflammationtreatment of diabetic retinopathy

Identifiers

PMID34708739
PMCPMC8725076
OpenAlexW3208700191

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.