Evidence map›Paper›PMID 34709141›Full record

ArticleJournal of clinical and experimental neuropsychology2021

Self-reported subjective cognitive decline is associated with global cognition in a community sample of Latinos/as/x living in the United States.

Marina Z Nakhla, Lynn Cohen, David P Salmon, Denis S Smirnov, María J Marquine, Alison A Moore, Dawn M Schiehser, Zvinka Z Zlatar

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Subjective cognitive decline among diverse older adults: Prevalence and associations with objective cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marina Z NakhlaSan Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA.
Lynn CohenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
David P SalmonDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Denis S SmirnovDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
María J MarquineDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Alison A MooreDepartment of Medicine, Division of Geriatrics, Gerontology and Palliative Care, University of California, San Diego, La Jolla, CA, USA.
Dawn M SchiehserDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Zvinka Z ZlatarDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/LatinosR01AG066657 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZLATAR, ZVINKA ZOE · 2021 to 2025
$3.8M
A Novel Mobile Health Exercise Intervention in Aging: Brain Perfusion and CognitionK23AG049906 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZLATAR, ZVINKA ZOE · 2016 to 2022
$888k
Traumatic Brain Injury in Parkinson’s Disease: A Longitudinal StudyI01CX001925 · VA · VETERANS HEALTH ADMINISTRATION · PI Dawn M. Schiehser · 2020 to 2026
–
Mindfulness Based Stress Reduction for Parkinson's Disease: A Longitudinal StudyI01RX003154 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI SCHIEHSER, DAWN M. · 2020 to 2024
–
CSRD VA I01 CX001925NCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1 TR001881NIA NIH HHS K23 AG049906NIA NIH HHS P30 AG021684NIA NIH HHS P30 AG059299NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG066657RRD VA I01 RX003154
6 · The paper itself

Abstract

introductionAlthough subjective cognitive decline (SCD) may be an early risk marker of Alzheimer's Disease (AD), research on SCD among Hispanics/Latinos/as/x (henceforth Latinos/as) living in the U.S. is lacking. We investigated if the cross-sectional relationship of self-reported SCD with objective cognition varies as a function of ethnic background (Latinos/as versus Non-Hispanic Whites [NHWs]). Secondary analyses conducted solely within the Latino/a group investigated if informant reported SCD is associated with objective cognition and whether self-reported SCD is related to markers of brain health in a sub-sample of Latinos/as with available MRI data.

methodsEighty-three participants (≥60 years of age) without dementia (35 Latinos/as; 48 NHWs) completed the Mattis Dementia Rating Scale (MDRS) and the Subjective Cognitive Decline-Questionnaire (SCD-Q). Additionally, 22 Latino/a informants completed the informant-version of the SCD-Q. Hierarchical regression models investigated if ethnicity moderates the association of MDRS and SCD-Q scores after adjusting for demographics and depressive symptoms. Correlational analyses within the Latino/a group investigated self- and informant-reported associations of SCD-Q scores with objective cognition, and associations of self-reported SCD-Q scores with medial temporal lobe volume and thickness.

resultsLatinos/as had lower education and MDRS scores than NHWs. Higher SCD-Q scores were associated with lower MDRS scores only in Latinos/as. Within the Latino/a group, self, but not informant reported SCD was related to objective cognition. Medium to large effect sizes were found whereby higher self-reported SCD was associated with lower entorhinal cortex thickness and left hippocampal volume in Latinos/as.

conclusionsThe association of SCD and concurrent objectively measured global cognition varied by ethnic background and was only significant in Latinos/as. Self-reported SCD may be an indicator of cognitive and brain health in Latinos/as without dementia, prompting clinicians to monitor cognition. Future studies should explore if SCD predicts objective cognitive decline in diverse groups of Latinos/as living in the U.S.

Indexed as

Cognitive DysfunctionCognitionHispanic or LatinoHumansNeuropsychological TestsSelf ReportUnited StatesHispanicsinformantmedial temporal lobestudy partnersubjective memory complaints

Identifiers

PMID34709141
PMCPMC8720066
OpenAlexW3211262491

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.