Evidence map›Paper›PMID 34713634›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Biomimicking Bone-Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment.

Wenting Li, Wei Qiao, Xiao Liu, Dong Bian, Danni Shen, Yufeng Zheng, Jun Wu, Kenny Y H Kwan, Tak Man Wong, Kenneth M C Cheung and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 72 citations in OpenAlex.

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  2. Materials today. Bio · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Wenting LiSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Wei QiaoDepartment of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0002-0450-0366
Xiao LiuSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Dong BianDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Danni ShenSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.ORCID 0000-0002-7402-9979
Jun WuShenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Kenny Y H KwanDepartment of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Tak Man WongDepartment of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Kenneth M C CheungDepartment of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Kelvin W K YeungDepartment of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0003-0887-088X
University of Hong Kong - Shenzhen Hospital · CNPeking University · CNGuangdong Academy of Medical Sciences · CN

Funding

Health and Medical Research Fund 19180712National key R&D Program of China 2018YFC1105100National Natural Science Foundation of China 51871004NSFC/RGC Joint Research Scheme 51661165014NSFC/RGC Joint Research Scheme N_HKU725/16Research Grants Council, University Grants Committee 17214516Shenzhen Science and Technology Funds JSGG20180507183242702
6 · The paper itself

Abstract

The most critical factor determining the success of biodegradable bone implants is the host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium-based implant, namely magnesium-silicon-calcium (Mg-0.2Si-1.0Ca) alloy, that coordinates its biodegradation along with the bone regenerative process via a self-assembled, multilayered bone-implant interface is designed. At first, its rapid biocorrosion contributes to a burst release of Mg

Indexed as

Absorbable ImplantsMagnesiumAlloysAnimalsBiomimetic MaterialsBone Diseases, MetabolicBone-Implant InterfaceCalcification, PhysiologicCellular MicroenvironmentDisease Models, AnimalFemaleRatsRats, Sprague-DawleyAlloysMagnesiumbone-implant interfacesimmunomodulationmagnesium alloyosteogenesisosteointegration

Identifiers

PMID34713634
PMCPMC8655172
OpenAlexW3209031563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.