Trial reportJournal of the American Heart Association2021
Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The Effect of Red Meat Consumption on Circulating, Urinary, and Fecal Trimethylamine-N-Oxide: A Systematic Review and Narrative Synthesis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- The Impact of Egg Consumption on Gastrointestinal Health: A Systematic Literature Review and Meta-Analysis.Nutrients · 2025Pooled it
- Modulating effects of microbiota on synbiotic intervention outcomes for microbiota-derived trimethylamine, trimethylamine N-oxide and indoxyl sulfate in healthy young medical students: insights from a 12-week randomized clinical trial.Journal of translational medicine · 2025Trial
- Effect of Varying Quantities of Lean Beef as Part of a Mediterranean-Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial.Journal of the American Heart Association · 2025Trial
- From Fecal Microbial Potential to Circulating Trimethylamine N-oxide and Cardiovascular Events: A Narrative Review.Cureus · 2026Review
- Gut bacteria associated with an atherogenic TMAO-dietary pattern and choline-rich foods among aging women.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026Article
- Gut microbe-derivedProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Soy and the gut microbiome: a bi-directional relationship shaping nutrition and health.European journal of nutrition · 2026Review
- Metagenome-assembled genomes reveal microbial signatures and metabolic pathways linked to coronary artery disease.mSystems · 2025Article
- Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Colon Microbiome In Vitro.Metabolites · 2025Article
- Article
- Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.Circulation research · 2025Review
- Gut Microbiota Metabolite TMAO and Adolescent Cardiometabolic Health: A Cross-sectional Analysis.Journal of the Endocrine Society · 2025Article
- Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas.Antioxidants (Basel, Switzerland) · 2025Article
- The gut microbiota in thrombosis.Nature reviews. Cardiology · 2025Review
- Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma.Biomedicines · 2024Article
- Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats.Cardiovascular diabetology · 2024Article
- Benefits of Taurisolo in Diabetic Patients with Peripheral Artery Disease.Journal of cardiovascular development and disease · 2024Article
- Article
- Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome.Frontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Marc FerrellDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
Peter BazeleyDepartment of Quantitative Health Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
Zeneng WangDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-6455-8228
Bruce S LevisonDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
Xinmin S LiDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.
Xun JiaDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-1746-8879
Ronald M KraussUniversity of California San Francisco Oakland CA.ORCID 0000-0002-1238-3489
Rob KnightDepartment of Pediatrics Department of Computer Science and Engineering Department of Bioengineering, and The Center for Microbiome Innovation University of California, San Diego La Jolla CA.ORCID 0000-0002-0975-9019
Aldons J LusisDepartments of Human Genetics and Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA.ORCID 0000-0001-9013-0228
J C Garcia-GarciaLife Sciences Transformative Platform Technologies Procter & Gamble Cincinnati OH.
Stanley L HazenDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.ORCID 0000-0001-7124-6639
W H Wilson TangDepartment of Cardiovascular and Metabolic Sciences Lerner Research Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-8335-735X
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USProcter & Gamble (United States) · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of California, San Francisco · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MSystems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6MDiet, Gut Microbiota, and Heart FailureR01HL126827 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2016 to 2019
$3.1MSystems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0MDietary Choline, Gut Microbiota, and Susceptibility for Chronic Kidney DiseaseR01DK106000 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2015 to 2018
$2.8MGut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6MCWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9MMicrobial Trimethylamine Lyases and AtherosclerosisR01HL130819 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, ZENENG · 2016 to 2019
$1.7MNHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL126827NHLBI NIH HHS R01 HL130819NHLBI NIH HHS R01 HL144651NHLBI NIH HHS R01 HL147883NHLBI NIH HHS T32 HL134622NIDDK NIH HHS R01 DK106000NIDDK NIH HHS R01 DK117850NIGMS NIH HHS T32 GM007250
Abstract
Background Trimethylamine-
Indexed as
MicrobiotaAdultBacteriaCholineCross-Over StudiesDietFecesGastrointestinal MicrobiomeHumansLyasesMethylaminesCholineLyasesMethylaminestrimethyloxaminefecal microbiomemetagenomicstrimethylamine lyasetrimethylamine N‐oxide
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.