Evidence map›Paper›PMID 34713802›Full record

ArticleeLife2021

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity.

Chad W Sauvola, Yulia Akbergenova, Karen L Cunningham, Nicole A Aponte-Santiago, J Troy Littleton

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. CaeLife · 2024
    Article
  6. CabioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chad W SauvolaDepartment of Brain and Cognitive Sciences, The Picower Institute of Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Yulia AkbergenovaDepartment of Brain and Cognitive Sciences, The Picower Institute of Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Karen L CunninghamDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Nicole A Aponte-SantiagoDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
J Troy LittletonDepartment of Brain and Cognitive Sciences, The Picower Institute of Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-5576-2887
Massachusetts Institute of Technology · USBaylor College of Medicine · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
CHARACTERIZATION OF THE DROSOPHILA SYNAPTOTAGMIN FAMILYR01NS040296 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2000 to 2024
$7.9M
Imaging Synaptic Transmission of Individual Active ZonesR01MH104536 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI J. TROY LITTLETON · 2014 to 2026
$4.7M
NIGMS NIH HHS T32 GM007287NIH HHS P40 OD018537NIMH NIH HHS R01 MH104536NINDS NIH HHS R01 NS040296
6 · The paper itself

Abstract

Synaptic vesicle (SV) release probability (

Indexed as

Neuronal PlasticityAnimalsDrosophila melanogasterDrosophila ProteinsHomeostasisMaleSNARE ProteinsDrosophila ProteinsSNARE ProteinsD. melanogasterDrosophilaneuroscienceneurotransmitter releasesnare complexsynapsesynaptic plasticitysynaptic vesicle

Identifiers

PMID34713802
PMCPMC8612732
OpenAlexW3209711083

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.