ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021
Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL
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Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Keggin-Type Polyoxometalates as a Systematic Antiviral Scaffold: Activity, Cytotoxicity, and Solution Stability across Heteroion and Addenda Metal Variations.Journal of medicinal chemistry · 2026Article
- Bulkiness Makes the Difference: Modulating Solid-State Emission of Anticoronavirus Active Pt(tpy)C(O)NHCH2R Complexes Featuring Adamantyl vs Propargyl R Groups.Inorganic chemistry · 2026Article
- Targeting SARS-CoV-2 Structural and Accessory Proteins: Emerging Opportunities for Small-Molecule Coronavirus Antivirals.Pharmaceutics · 2026Review
- Isolable Phosphonioacetylides as Strong Neutral Carbon Donors with Variable Steric Demand and Tunable Donor Properties.Inorganic chemistry · 2026Article
- Structural Basis and Inhibitor Development of SARS-CoV-2 Papain-like Protease.Molecules (Basel, Switzerland) · 2026Review
- SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties.ACS omega · 2025Article
- Recent Advances in the Development of Metal-Glycoconjugates for Medicinal Applications.Molecules (Basel, Switzerland) · 2025Review
- Au(I)-based compounds inhibit nsp14/nsp10 and nsp13 (helicase) to exert anti-SARS-CoV-2 properties.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Article
- Searching for New Gold(I)-Based Complexes as Anticancer and/or Antiviral Agents.Molecules (Basel, Switzerland) · 2025Review
- Antibacterial and Anti-Influenza Activities ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Mechanistic insights into bismuth(iii) inhibition of SARS-CoV-2 helicase.Chemical science · 2024Article
- NHCs silver complexes as potential antimicrobial agents.Inorganica chimica acta · 2024Article
- Article
- Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives.ACS infectious diseases · 2024Article
- Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2.RSC medicinal chemistry · 2023Article
- The Metallodrug BOLD-100 Is a Potent Inhibitor of SARS-CoV-2 Replication and Has Broad-Acting Antiviral Activity.Biomolecules · 2023Article
- Speciation atlas of polyoxometalates in aqueous solutions.Science advances · 2023Article
- In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography.Scientific reports · 2023Article
- Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads.Journal of medicinal chemistry · 2023Article
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Authors and funding
41 authors at 9 institutions in 6 countries.
Maria Gil-MolesInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Sebastian TürckInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Uttara BasuInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-0509-2421
Andrea PettenuzzoSchool of Chemistry, National University of Ireland Galway, University Road, H91 TK33, Galway, Ireland.ORCID http://orcid.org/0000-0002-1127-3894
Saurav BhattacharyaDepartment of Life Sciences and Chemistry, Jacobs University, Campus Ring 1, 28759, Bremen, Germany.ORCID http://orcid.org/0000-0002-3396-8312
Ananthu RajanDepartment of Life Sciences and Chemistry, Jacobs University, Campus Ring 1, 28759, Bremen, Germany.ORCID http://orcid.org/0000-0001-9079-178X
Xiang MaDepartment of Life Sciences and Chemistry, Jacobs University, Campus Ring 1, 28759, Bremen, Germany.
Rolf BüssingInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Jessica WölkerInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Hilke BurmeisterInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Henrik HoffmeisterInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Pia SchneebergInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Andre PrauseInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Petra LippmannInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.
Josephine Kusi-NimarkoDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, Brighton, East Sussex, UK.
Storm Hassell-HartDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, Brighton, East Sussex, UK.
Andrew McGownDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, Brighton, East Sussex, UK.
Daniel GuestDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, Brighton, East Sussex, UK.
Yan LinChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.ORCID http://orcid.org/0000-0001-7808-5444
Anna NotaroChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.
Robin VinckChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.ORCID http://orcid.org/0000-0002-2730-0121
Johannes KargesChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.ORCID http://orcid.org/0000-0001-5258-0260
Kevin CariouChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.ORCID http://orcid.org/0000-0002-5854-9632
Kun PengInstitut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6885-9899
Xue QinLCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Xing WangLCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Joanna SkibaFaculty of Chemistry, Department of Organic Chemistry, University of Łódź, Tamka 12, 91-403, Łódź, Poland.ORCID http://orcid.org/0000-0003-0014-8366
Łukasz SzczupakFaculty of Chemistry, Department of Organic Chemistry, University of Łódź, Tamka 12, 91-403, Łódź, Poland.ORCID http://orcid.org/0000-0002-2620-2466
Konrad KowalskiFaculty of Chemistry, Department of Organic Chemistry, University of Łódź, Tamka 12, 91-403, Łódź, Poland.ORCID http://orcid.org/0000-0003-0600-3205
Ulrich SchatzschneiderInstitut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Catherine HemmertLCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France.ORCID http://orcid.org/0000-0002-8122-5177
Heinz GornitzkaLCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France.ORCID http://orcid.org/0000-0002-8838-5907
Elena R MilaevaDepartment of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, 119991, Moscow, Russia.ORCID http://orcid.org/0000-0002-5489-3866
Alexey A NazarovDepartment of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, 119991, Moscow, Russia.ORCID http://orcid.org/0000-0002-5821-1658
Gilles GasserChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.ORCID http://orcid.org/0000-0002-4244-5097
John SpencerDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, Brighton, East Sussex, UK.ORCID http://orcid.org/0000-0001-5231-8836
Luca RonconiSchool of Chemistry, National University of Ireland Galway, University Road, H91 TK33, Galway, Ireland.ORCID http://orcid.org/0000-0002-8420-8364
Ulrich KortzDepartment of Life Sciences and Chemistry, Jacobs University, Campus Ring 1, 28759, Bremen, Germany.ORCID http://orcid.org/0000-0002-5472-3058
Jindrich CinatlInstitute of Medical Virology, Universitätsklinikum Frankfurt, Paul-Ehrlich-Str. 40, 60596, Frankfurt, Germany.
Denisa BojkovaInstitute of Medical Virology, Universitätsklinikum Frankfurt, Paul-Ehrlich-Str. 40, 60596, Frankfurt, Germany.
Ingo OttInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-8087-4618
Technische Universität Braunschweig · DECentre National de la Recherche Scientifique · FRUniversity of Sussex · GBConstructor University · DEUniversity of Łódź · PLGoethe University Frankfurt · DELomonosov Moscow State University · RUOllscoil na Gaillimhe – University of Galway · IEUniversity of Würzburg · DE
Funding
European Research Council
Abstract
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns, however, there is growing evidence for their role in medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal complexes for profiling as inhibitors of two relevant SARS-CoV-2 replication mechanisms, namely the interaction of the spike (S) protein with the ACE2 receptor and the papain-like protease PL
Indexed as
SARS-CoV-2Angiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus Papain-Like ProteasesSpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus Papain-Like Proteasespapain-like protease, SARS-CoV-2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2gold, metallodrugsPLpropolyoxometalatesSARS-CoV-2silverspike proteintitanocene
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.