Evidence map›Paper›PMID 34716317›Full record

ArticleCell death discovery2021

Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.

Na Zhou, Weijiang Liu, Wei Zhang, Yuanlin Liu, Xue Li, Yang Wang, Rongxiu Zheng, Yi Zhang

Open access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Advancements in diabetes research and stem cell therapy: a concise review.Journal of diabetes and metabolic disorders · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Na Zhou *Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China.ORCID http://orcid.org/0000-0001-6211-2946
Weijiang Liu *Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China.ORCID http://orcid.org/0000-0002-3872-7382
Wei Zhang *Department of Medical Administration, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.ORCID http://orcid.org/0000-0001-5529-2985
Yuanlin LiuDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China.ORCID http://orcid.org/0000-0001-9614-2908
Xue LiDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China.ORCID http://orcid.org/0000-0002-6969-0674
Yang WangDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China.ORCID http://orcid.org/0000-0003-3126-3367
Rongxiu ZhengDepartment of Pediatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China. rzheng@tmu.edu.cn.ORCID http://orcid.org/0000-0001-6118-0218
Yi ZhangDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, 100850, China. zhangyi612@hotmail.com.ORCID http://orcid.org/0000-0003-2498-3948
Tianjin Medical University General Hospital · CNCapital Institute of Pediatrics · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) show significant therapeutic effects in type 1 diabetes mellitus (T1DM) as regulating the inflammatory processes. However, little is known about the detailed process of MSCs immunosuppression in T1DM. In this study, we investigated the effects of wild-type p53-induce phosphatase 1 (Wip1) on regulating MSCs immunosuppressive capacities in T1DM mice. We found that Wip1 knockout (Wip1

Identifiers

PMID34716317
PMCPMC8556269
OpenAlexW3212973415

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.