Evidence map›Paper›PMID 34716732›Full record

ReviewPsychiatry and clinical neurosciences2022

Trends in big data analyses by multicenter collaborative translational research in psychiatry.

Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto and 6 more

Abstract readReview
In one paragraph

Review in Psychiatry and clinical neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Toshiaki OnitsukaDepartment of Neuroimaging Psychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID https://orcid.org/0000-0001-6583-6405
Yoji HiranoDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID https://orcid.org/0000-0001-6847-9677
Kiyotaka NemotoDepartment of Psychiatry, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-8623-9829
Naoki HashimotoDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.ORCID https://orcid.org/0000-0001-8311-7148
Itaru KushimaDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-0018-5178
Daisuke KoshiyamaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Michihiko KoedaDepartment of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Tsutomu TakahashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Yoshihiro NodaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2155-0357
Junya MatsumotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4228-3208
Kenichiro MiuraDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takanobu NakazawaDepartment of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4863-1277
Takatoshi HikidaLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-8653-311X
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4443-4535
Norio OzakiDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-7360-4898
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5941-4238

Funding

Grant-in-Aid for Scientific Research JP18K07604Grant-in-Aid for Scientific Research JP19H03579Grant-in-Aid for Scientific Research JP21H02851Japan Agency for Medical Research and Development JP18dm0207004Japan Agency for Medical Research and Development JP20dm0207069Japan Agency for Medical Research and Development JP20dm0307002Japan Agency for Medical Research and Development JP21dk0307103Japan Agency for Medical Research and Development JP21dm0307001Japan Agency for Medical Research and Development JP21uk1024002Japan Society for the Promotion of Science 18K07550Japan Society for the Promotion of Science 18K15375Japan Society for the Promotion of Science 21H02813Japan Society for the Promotion of Science JP18KT0022Japan Society for the Promotion of Science JP19H05467Japan Society for the Promotion of Science JP20H03611Japan Society for the Promotion of Science JP20KK0193JSPS KAKENHI 20JSPS KAKENHI 20K06920JSPS KAKENHI 21H00194JSPS KAKENHI 21K07543JSPS KAKENHI 21K12153JSPS KAKENHI JP16H06280JSPS KAKENHI JP16H06395JSPS KAKENHI JP16H06399JSPS KAKENHI JP16K21720JSPS KAKENHI JP18H02542
6 · The paper itself

Abstract

The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory-based research that incorporates the latest findings, it is necessary to conduct large-sample-size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology, and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders.

Indexed as

Big DataData AnalysisMental DisordersMulticenter Studies as TopicPsychiatryTranslational Research, BiomedicalAnimalsHumansMeta-Analysis as TopicNeuroimagingReproducibility of Resultsautism spectrum disorderbipolar disorderCOCOROmajor depressive disorderschizophrenia

Identifiers

PMID34716732
PMCPMC9306748

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.