Evidence map›Paper›PMID 34718484›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2021

Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers.

Dana C Peters, Jérôme Lamy, Albert J Sinusas, Lauren A Baldassarre

Open access · greenAbstract read
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 51 citations in OpenAlex.

  1. Atorvastatin and left atrial function during anthracycline-based chemotherapy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Trial
  2. Article
  3. Review
  4. Review
  5. Prospective serial cardiovascular magnetic resonance imaging of immune checkpoint inhibitor myocarditis correlates with cardiovascular outcomes.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  6. Article
  7. Article
  8. Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025
    Article
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  10. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dana C PetersDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7556-4642
Jérôme LamyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Albert J SinusasDepartment of Cardiology, Yale School of Medicine, New Haven, CT, USA.
Lauren A BaldassarreDepartment of Cardiology, Yale School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development of MR-derived parameters of LV diastolic function: Validation and Comparison to LV and LA fibrosisR01HL144706 · NHLBI · YALE UNIVERSITY · PI PETERS, DANA C · 2019 to 2022
$1.8M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL144706
6 · The paper itself

Abstract

Left atrial (LA) imaging is still not routinely used for diagnosis and risk stratification, although recent studies have emphasized its importance as an imaging biomarker. Cardiovascular magnetic resonance is able to evaluate LA structure and function, metrics that serve as early indicators of disease, and provide prognostic information, e.g. regarding diastolic dysfunction, and atrial fibrillation (AF). MR angiography defines atrial anatomy, useful for planning ablation procedures, and also for characterizing atrial shapes and sizes that might predict cardiovascular events, e.g. stroke. Long-axis cine images can be evaluated to define minimum, maximum, and pre-atrial contraction LA volumes, and ejection fractions (EFs). More modern feature tracking of these cine images provides longitudinal LA strain through the cardiac cycle, and strain rates. Strain may be a more sensitive marker than EF and can predict post-operative AF, AF recurrence after ablation, outcomes in hypertrophic cardiomyopathy, stratification of diastolic dysfunction, and strain correlates with atrial fibrosis. Using high-resolution late gadolinium enhancement (LGE), the extent of fibrosis in the LA can be estimated and post-ablation scar can be evaluated. The LA LGE method is widely available, its reproducibility is good, and validations with voltage-mapping exist, although further scan-rescan studies are needed, and consensus regarding atrial segmentation is lacking. Using LGE, scar patterns after ablation in AF subjects can be reproducibly defined. Evaluation of 'pre-existent' atrial fibrosis may have roles in predicting AF recurrence after ablation, predicting new-onset AF and diastolic dysfunction in patients without AF. LA imaging biomarkers are ready to enter into diagnostic clinical practice.

Indexed as

Atrial FibrillationCatheter AblationBiomarkersContrast MediaFibrosisGadoliniumHeart AtriaHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyReproducibility of ResultsBiomarkersContrast MediaGadoliniumcardiovascular magnetic resonancefibrosislate gadolinium enhancementleft atriumstrainstrain ratevolume

Identifiers

PMID34718484
PMCPMC8685602
OpenAlexW3209073390

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.