ArticleThe Plant cell2022
Misregulation of MYB16 expression causes stomatal cluster formation by disrupting polarity during asymmetric cell divisions.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Transcriptional control of cuticle formation during development.Journal of experimental botany · 2026Review
- A small peptide APP3-14 disrupts pathogen-insect mutualism by modulating plant MYC2-mediated olfactory defense.Plant communications · 2025Article
- Genetic control of prickles in tetraploid blackberry.G3 (Bethesda, Md.) · 2025Article
- Challenges of translating Arabidopsis insights into crops.The Plant cell · 2025Review
- Pan-genome analysis reveals the evolution and diversity of Malus.Nature genetics · 2025Article
- Wheat WW Domain-Containing Protein TaCFL1 Negatively Regulates Cuticular Wax Biosynthesis.International journal of molecular sciences · 2024Article
- Wheat Transcription Factor TaMYB60 Modulates Cuticular Wax Biosynthesis by ActivatingInternational journal of molecular sciences · 2024Article
- Wheat MIXTA-like Transcriptional Activators Positively Regulate Cuticular Wax Accumulation.International journal of molecular sciences · 2024Article
- Conserved signalling components coordinate epidermal patterning and cuticle deposition in barley.Nature communications · 2022Article
- Sclerotinia sclerotiorum SsCut1 Modulates Virulence and Cutinase ActivityJournal of fungi (Basel, Switzerland) · 2022Article
- MYB16 expression in the stomatal lineage: Wrong place at the wrong time leads to stomata side-by-side.The Plant cell · 2022Article
- Back to the roots: A focus on plant cell biology.The Plant cell · 2022Article
- Using quantitative methods to understand leaf epidermal development.Quantitative plant biology · 2022Review
- Stomatal development and genetic expression inHeliyon · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stomatal pores and the leaf cuticle regulate evaporation from the plant body and balance the tradeoff between photosynthesis and water loss. MYB16, encoding a transcription factor involved in cutin biosynthesis, is expressed in stomatal lineage ground cells, suggesting a link between cutin biosynthesis and stomatal development. Here, we show that the downregulation of MYB16 in meristemoids is directly mediated by the stomatal master transcription factor SPEECHLESS (SPCH) in Arabidopsis thaliana. The suppression of MYB16 before an asymmetric division is crucial for stomatal patterning, as its overexpression or ectopic expression in meristemoids increased stomatal density and resulted in the formation of stomatal clusters, as well as affecting the outer cell wall structure. Expressing a cutinase gene in plants ectopically expressing MYB16 reduced stomatal clustering, suggesting that cutin affects stomatal signaling or the polarity setup in asymmetrically dividing cells. The clustered stomatal phenotype was rescued by overexpressing EPIDERMAL PATTERNING FACTOR2, suggesting that stomatal signaling was still functional in these plants. Growing seedlings ectopically expressing MYB16 on high-percentage agar plates to modulate tensile strength rescued the polarity and stomatal cluster defects of these seedlings. Therefore, the inhibition of MYB16 expression by SPCH in the early stomatal lineage is required to correctly place the polarity protein needed for stomatal patterning during leaf morphogenesis.
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