ArticleCell discovery2021
Discovery of new genetic loci for male sexual orientation in Han population.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Probing the genomic landscape of human sexuality: a critical systematic review of the literature.Frontiers in genetics · 2023Pooled it
- Biological, genetic, neurological and environmental influences on homosexuality-a narrative review.Frontiers in behavioral neuroscience · 2025Review
- Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells.Frontiers in molecular neuroscience · 2025Article
- The methodological and ethical concerns of genetic studies of same-sex sexual behavior.American journal of human genetics · 2024Review
- Same-sex sociosexual behaviour is widespread and heritable in male rhesus macaques.Nature ecology & evolution · 2023Article
- LGBTQ+ Perspectives on Conducting Genomic Research on Sexual Orientation and Gender Identity.Behavior genetics · 2022Article
- Author Correction: Discovery of new genetic loci for male sexual orientation in Han population.Cell discovery · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
53 authors at 11 institutions in 3 countries.
Shao-Hua Hu *Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hai-Mei Li *Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hao Yu *Department of Psychiatry, Jining Medical University, 133 Hehua Rd, Jining, Shandong, China.
Yan Liu *Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Chen-Xing LiuDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Xian-Bo ZuoInstitute of Dermatology and Department of Dermatology at First Hospital, Anhui Medical University, Hefei, Anhui, China.
Jing LuDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jia-Jun JiangDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Cai-Xi XiDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Bo-Chao HuangDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hu-Ji XuDepartment of General Office, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China.
Jian-Bo HuDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jian-Bo LaiDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Man-Li HuangDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jian-Ning LiuDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Dan-Ge XuState Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xi-Chao GuoDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wei WuState Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xin WuDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medial University, Shanghai, China.
Lei JiangDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medial University, Shanghai, China.
Meng LiDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medial University, Shanghai, China.
Guang-Ping ZhangDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jin-Wen HuangDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Ning WeiDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wen LvDepartment of Psychiatry, Seventh Hangzhou Hospital, Hangzhou, Zhejiang, China.
Jin-Feng DuanDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hong-Li QiDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chan-Chan HuDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jing-Kai ChenDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wei-Hua ZhouDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wei-Juan XuDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chen-Feng LiuMedicines&Biochemical Products Branch, Zhejiang Medicine &Health Products I/E CO., Ltd, Hangzhou, Zhejiang, China.
Hai-Yong LiangBioMiao Biological Technology (Beijing) Co., Ltd, Beijing, China.
Jing DuBeijing Emei Tongde Technology Development Co., Ltd, Beijing, China.
Shu-Fa ZhengDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Qiao-Ling LuDepartment of Aids Venereal Disease Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang, China.
Lin ZhengDepartment of Prevention and Treatment of AIDS and Sexually Transmitted Diseases, Center for Disease Control and Prevention of Xihu District, Hangzhou, Zhejiang, China.
Xiao-Wei HuDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Feng-Xiang ChenDepartment of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Peng ChenInternational medical center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Biao ZhuDepartment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Li-Jun XuDepartment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhi-Min NiDepartment of Disease Control, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China.
Ye-Zhen FangDepartment of Laboratory, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China.
Zuo-Kai YangDepartment of Aids Venereal Disease Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang, China.
Xin-Ren ShanDepartment of Aids Venereal Disease Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang, China.
En-de ZhengBeijing ViewSolid Biotechnology, Beijing, China.
Fan ZhangShanghai OE Biotech. Co., Ltd, Beijing, China.
Qing-Qing ZhouShanghai OE Biotech. Co., Ltd, Beijing, China.
Yi RaoDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Dick SwaabNetherlands Institute for Neuroscience, Amsterdam, 1105 BA, The Netherlands.
Wei-Hua YueInstitute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China. dryue@bjmu.edu.cn.
Yi XuDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. xuyizju@zju.edu.cn.ORCID http://orcid.org/0000-0002-5246-7812
First Affiliated Hospital Zhejiang University · CNSecond Military Medical University · CNZhejiang Center for Disease Control and Prevention · CNCapital Medical University · CNUniversity of Pittsburgh · USAnhui Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHangzhou Seventh Peoples Hospital · CNJining Medical University · CNNetherlands Institute for Neuroscience · NLZhejiang Lab · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, potentially missing important biological insights. Here, we performed a two-stage genome-wide association study (GWAS) with a total sample of 1478 homosexual males and 3313 heterosexual males in Han Chinese populations and identified two genetic loci (rs17320865, Xq27.3, FMR1NB, P
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.