Evidence map›Paper›PMID 34719934›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.

Michael A Francisco, Joshua F Lee, Zachary Barrett-O'Keefe, H Jonathan Groot, Stephen M Ratchford, Kanokwan Bunsawat, Jeremy K Alpenglow, John J Ryan, Jose N Nativi, Russell S Richardson and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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  7. Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael A Francisco *Department of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.ORCID 0000-0003-3392-4245
Joshua F Lee *Department of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.
Zachary Barrett-O'KeefeDepartment of Nutrition and Integrative Physiology (Z.B.-O., H.J.G., R.S.R., D.W.W.), University of Utah, Salt Lake City.
H Jonathan GrootDepartment of Nutrition and Integrative Physiology (Z.B.-O., H.J.G., R.S.R., D.W.W.), University of Utah, Salt Lake City.
Stephen M RatchfordGeriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, UT (M.A.F., J.F.L., Z.B.-O., H.J.G., S.M.R., J.K.A., R.S.R., D.W.W.).ORCID 0000-0002-6300-7600
Kanokwan BunsawatDepartment of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.ORCID 0000-0002-5950-6634
Jeremy K AlpenglowGeriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, UT (M.A.F., J.F.L., Z.B.-O., H.J.G., S.M.R., J.K.A., R.S.R., D.W.W.).
John J RyanDepartment of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.ORCID 0000-0002-9203-5512
Jose N NativiDepartment of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.ORCID 0000-0002-5481-2122
Russell S RichardsonDepartment of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.
D Walter WrayDepartment of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City.
University of Utah · USGeriatric Research Education and Clinical Center · US

Funding

Peripheral Vasoconstriction in Heart Failure: Mechanisms & Modulatory InfluencesR01HL118313 · NHLBI · UNIVERSITY OF UTAH · PI WRAY, D. WALTER · 2014 to 2018
$1.9M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Exercise and Cognitive Function in Alzheimers Disease Progression: Role of the Vascular EndotheliumR56AG057584 · NIA · UNIVERSITY OF UTAH · PI RICHARDSON, RUSSELL S. · 2018 to 2018
$658k
Novel Approaches for Improving Vascular Function in Veterans with HFpEFI01CX002152 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI D. Walter Wray · 2021 to 2026
–
Rehabilitation for Hypertension: Exercise and Skeletal Muscle Afferent FeedbackI21RX001433 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2014 to 2015
–
Overcoming Exercise Intolerance in Veterans with Heart Failure: The Role of NO.I01RX001311 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI WRAY, D. WALTER · 2017 to 2020
–
Passive limb movement: A tool to assess vascular health and guide rehabilitationI01RX001697 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2015 to 2018
–
CSRD VA I01 CX002152NHLBI NIH HHS R01 HL118313NHLBI NIH HHS T32 HL139451NIA NIH HHS R56 AG057584RRD VA I01 RX001311RRD VA I01 RX001697RRD VA I21 RX001433
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AgedBlood PressureFemaleHeart Failure, DiastolicHeart RateHumansLegMaleMicrovesselsMuscle, SkeletalRegional Blood FlowStroke Volumebiomarkersheart failurehyperemiainflammationmuscles

Identifiers

PMID34719934
PMCPMC8585708
OpenAlexW3210516414

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.