Evidence map›Paper›PMID 34725640›Full record

ArticleBioMed research international2021

Natural Compounds from Hatikana Extract Potentiate Antidiabetic Actions as Displayed by In Vivo Assays and Verified by Network Pharmacological Tools.

Md Atiar Rahman, Md Nazim Uddin, Nouf Abubakr Babteen, Afnan M Alnajeebi, Zainul Amiruddin Zakaria, Salama Mostafa Aboelenin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Md Atiar RahmanDepartment of Biochemistry & Molecular Biology, University of Chittagong, Chittagong4331, Bangladesh.ORCID https://orcid.org/0000-0002-4902-8923
Md Nazim UddinInstitute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research, Dhaka 1205, Bangladesh.ORCID https://orcid.org/0000-0001-6586-5636
Nouf Abubakr BabteenDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.ORCID https://orcid.org/0000-0002-7836-5398
Afnan M AlnajeebiDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.ORCID https://orcid.org/0000-0002-5670-1688
Zainul Amiruddin ZakariaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, (Jalan UMS), 88400 Kota Kinabalu, Sabah, Malaysia.ORCID https://orcid.org/0000-0001-5525-7821
Salama Mostafa AboeleninBiology Department, Turabah University College, Taif University 21995, Saudi Arabia.
University of Jeddah · SABangladesh Council of Scientific and Industrial Research · BDTaif University · SAUniversiti Putra Malaysia · MYUniversity of Chittagong · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHatikana is a traditional medicinal plant used to treat inflammation, urolithiasis, goiter, cancer, wounds and sores, gastrointestinal, tumor, tetanus, arthritis, hepatic damage, neurodegeneration, and other ailments. The goal of this study is to investigate the antidiabetic properties of Hatikana extract (HKEx) and to construct the effects of its natural constituents on the genes and biochemical indices that are connected with them.

methodsHKEx was evaluated using GC-MS and undertaken for a three-week intervention in fructose-fed STZ-induced Wistar albino rats at the doses of HKEx50, HKEx100, and HKEx200 mg/kg bw. Following intervention, blood serum was examined for biochemical markers, and liver tissue was investigated for the mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD1) by RTPCR analysis. Most abundant compounds (oleanolic acid, 7

resultsIn vivo results showed a significant (

conclusionThe findings show that antioxidative genes have regulatory potential, allowing the HKEx to be employed as a possible antidiabetic source pending further validation.

Indexed as

Alanine TransaminaseAnimalsAntioxidantsAspartate AminotransferasesDiabetes Mellitus, ExperimentalGlutathione PeroxidaseHypoglycemic AgentsLiverMaleMedicine, TraditionalNetwork PharmacologyOxidative StressPlant ExtractsRatsRats, WistarSuperoxide DismutaseAlanine TransaminaseAntioxidantsAspartate AminotransferasesGlutathione PeroxidaseHypoglycemic AgentsPlant ExtractsSuperoxide Dismutase

Identifiers

PMID34725640
PMCPMC8557063
OpenAlexW3208681037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.