Evidence map›Paper›PMID 34728052›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

Mandibular advancement device treatment and reverse left ventricular hypertrophic remodeling in patients with obstructive sleep apnea.

Marijke Dieltjens, Olivier M Vanderveken, Bharati Shivalkar, Gilles Van Haesendonck, Chloé Kastoer, Hein Heidbuchel, Marc J Braem, Caroline M Van De Heyning

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02320877 (Evaluation of the Overall Effectiveness Including Cardiovascular Effects of the Custom-made, Titratable Duoblock Flex SomnoDent® MAS in the Treatment of Obstructive Sleep Apnea), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02320877 nacompletednot on this map

Evaluation of the Overall Effectiveness Including Cardiovascular Effects of the Custom-made, Titratable Duoblock Flex SomnoDent® MAS in the Treatment of Obstructive Sleep Apnea

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2014 to 2021Enrolled100ConditionsOSAArmsMandibular Advancement Device (Somnomed Flex)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. The role of oral appliance therapy in obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  5. Review
  6. Treatment options in obstructive sleep apnea.Internal and emergency medicine · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marijke DieltjensFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Olivier M VandervekenFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Bharati ShivalkarFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Gilles Van HaesendonckFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Chloé KastoerFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Hein HeidbuchelFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Marc J BraemFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Caroline M Van De HeyningFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
University of Antwerp · BEAntwerp University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) is associated with cardiovascular comorbidities such as left ventricular (LV) hypertrophy. Whether OSA is an independent etiological factor for this hypertrophic remodeling is yet unknown. Continuous positive airway pressure partially reverses this hypertrophy, but data regarding the effect of mandibular advancement devices on LV remodeling are scarce. The aim of this prospective trial is to evaluate the effect of mandibular advancement device therapy on LV geometry and function in patients with OSA.

methodsAt baseline and 6-month follow-up, participants underwent a home sleep apnea test, 24-hour ambulatory blood pressure monitoring and a 2-dimensional Doppler and tissue Doppler echocardiography.

resultsSixty-three patients (age: 49 ± 11 years; body mass index: 27.0 ± 3.4 kg/m

conclusionsIn mildly obese, normotensive patients with OSA we observed significant reverse hypertrophic remodeling after 6 months of successful mandibular advancement device therapy, with maintained normotensive systemic blood pressure. This suggests that OSA is an independent factor in the pathophysiology of LV hypertrophy in these patients. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Evaluation of the Cardiovascular Effects of the MAS in the Treatment of Obstructive Sleep Apnea; URL: https://clinicaltrials.gov/ct2/show/NCT02320877; Identifier: NCT02320877. CITATION: Dieltjens M, Vanderveken OM, Shivalkar B, et al. Mandibular advancement device treatment and reverse left ventricular hypertrophic remodeling in patients with obstructive sleep apnea.

Indexed as

Mandibular AdvancementSleep Apnea, ObstructiveAdultBlood Pressure Monitoring, AmbulatoryContinuous Positive Airway PressureHumansHypertrophyMiddle AgedOcclusal SplintsProspective StudiesTreatment Outcomecardiovascular aspectshypertrophic remodelingmandibular advancement treatment

Identifiers

PMID34728052
PMCPMC8883081
OpenAlexW3208639823

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.