Evidence map›Paper›PMID 34730396›Full record

ArticleJournal of virology2022

iTRAQ-Based Proteomics Analysis of Human Cytomegalovirus Latency and Reactivation in T98G Cells.

Shuang Cheng, Fei Zhao, Le Wen, Bo Yang, Xian-Zhang Wang, Sheng-Nan Huang, Xuan Jiang, Wen-Bo Zeng, Jin-Yan Sun, Fu-Kun Zhang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Mechanism and significance of cell senescence induced by viral infection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  2. Human cytomegalovirus and neonatal infection.Current research in microbial sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Shuang ChengState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Fei ZhaoSchool of Basic Medical Sciences, Capital Medical University, Beijing, China.
Le WenThe Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.
Bo YangThe Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.
Xian-Zhang WangState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Sheng-Nan HuangState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Xuan JiangThe Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.
Wen-Bo ZengState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Jin-Yan SunState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Fu-Kun ZhangChangchun Keygen Biological Products Co., Ltd., Changchun, China.
Hong-Jie ShenChangchun Keygen Biological Products Co., Ltd., Changchun, China.
Elizabeth FortunatoDepartment of Biological Sciences and Center for Reproductive Biology, University of Idahogrid.266456.5, Moscow, Idaho, USA.ORCID 0000-0003-2212-3645
Min-Hua LuoState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0001-9352-0643
Han ChengShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Chinese Academy of Sciences · CNChangchun Institute of Biological Products · CNCapital Medical University · CNShanghai Public Health Clinical Center · CNUniversity of Idaho · US

Funding

HCMV infection downregulates nidogen 1 and myelin protein zeroR01AI139503 · NIAID · UNIVERSITY OF IDAHO · PI ELIZABETH A FORTUNATO · 2018 to 2026
$2.9M
NIAID NIH HHS R01 AI139503
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) establishes a persistent/latent infection after primary infection, and the host factor(s) plays a key role in regulating HCMV infection status. The spread of reactivated HCMV via the hematogenous or neural route usually results in severe diseases in newborns and immunocompromised individuals. As the primary reservoirs

Indexed as

ProteomicsVirus ActivationVirus LatencyApolipoproteins ECell Line, TumorCytomegalovirusGene OntologyHumansPhosphatidylinositol 3-KinasesProtein Interaction MapsProteomeSignal TransductionApolipoproteins EPhosphatidylinositol 3-KinasesProteomeApoEhuman cytomegalovirusiTRAQ proteomicslatencyPI3KreactivationT98G cells

Identifiers

PMID34730396
PMCPMC8791298
OpenAlexW3211090306

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.