Evidence map›Paper›PMID 34731022›Full record

ReviewJournal of clinical microbiology2022

Clinical and Infection Prevention Applications of Severe Acute Respiratory Syndrome Coronavirus 2 Genotyping: an Infectious Diseases Society of America/American Society for Microbiology Consensus Review Document.

Alexander L Greninger, Jennifer Dien Bard, Robert C Colgrove, Erin H Graf, Kimberly E Hanson, Mary K Hayden, Romney M Humphries, Christopher F Lowe, Melissa B Miller, Dylan R Pillai and 3 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-7443-0527
Jennifer Dien BardDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-0524-9473
Robert C ColgroveDivision of Infectious Diseases, Mount Auburn Hospital, Harvard School of Medicine, Boston, Massachusetts, USA.
Erin H GrafDepartment of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a Arizona, Phoenix, Arizona, USA.ORCID 0000-0002-6014-4570
Kimberly E HansonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-9790-277X
Mary K HaydenDivision of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Romney M HumphriesDivision of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-6568-156X
Christopher F LoweDivision of Medical Microbiology and Virology, Providence Health Caregrid.415289.3, Vancouver, BC, Canada.ORCID 0000-0001-9320-4499
Melissa B MillerClinical Microbiology Laboratory, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA.
Dylan R PillaiDepartment of Pathology and Laboratory Medicine, University of Calgarygrid.22072.35, Alberta, Canada.
Daniel D RhoadsDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Joseph D YaoDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Francesca M LeeDivision of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

NCEZID CDC HHS U54 CK000481NCEZID CDC HHS U54 CK000607
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into a world of maturing pathogen genomics, with more than 2 million genomes sequenced at the time of writing. The rise of more transmissible variants of concern that impact vaccine and therapeutic effectiveness has led to widespread interest in SARS-CoV-2 evolution. Clinicians are also eager to take advantage of the information provided by SARS-CoV-2 genotyping beyond surveillance purposes. Here, we review the potential role of SARS-CoV-2 genotyping in clinical care. The review covers clinical use cases for SARS-CoV-2 genotyping, methods of SARS-CoV-2 genotyping, assay validation and regulatory requirements, and clinical reporting for laboratories, as well as emerging issues in clinical SARS-CoV-2 sequencing. While clinical uses of SARS-CoV-2 genotyping are currently limited, rapid technological change along with a growing ability to interpret variants in real time foretells a growing role for SARS-CoV-2 genotyping in clinical care as continuing data emerge on vaccine and therapeutic efficacy.

Indexed as

Communicable DiseasesCOVID-19GenotypeHumansSARS-CoV-2United Statesallele specificASMclinical applicationsconsensusgenomicsgenotypingIDSART-qPCRSARS-CoV-2sequencing

Identifiers

PMID34731022
PMCPMC8769737

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.