Evidence map›Paper›PMID 34732776›Full record

ArticleScientific reports2021

Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes.

Gokhan Dalgin, Andrew K Tryba, Ashley P Cohen, Soo-Young Park, Louis H Philipson, Siri Atma W Greeley, Alfredo J Garcia

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Neonatal diabetes mellitus around the world: Update 2024.Journal of diabetes investigation · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Growth and development in monogenic forms of neonatal diabetes.Current opinion in endocrinology, diabetes, and obesity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gokhan DalginSection of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Pediatrics, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA. gdalgin@gmail.com.
Andrew K TrybaSection of Pediatric Neurology, Department of Pediatrics, The University of Chicago, Chicago, IL, USA.
Ashley P CohenChicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.
Soo-Young ParkSection of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Pediatrics, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA.
Louis H PhilipsonSection of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Pediatrics, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA.
Siri Atma W GreeleySection of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Pediatrics, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA.
Alfredo J GarciaSection of Emergency Medicine, Department of Medicine, Institute for Integrative Physiology, Grossman Institute for Neuroscience, The University of Chicago, Chicago, USA. ajgarcia3@uchicago.edu.
University of Chicago · USRosalind Franklin University of Medicine and Science · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Monogenic Diabetes: Next Generation Diagnosis, Treatment and ComplicationsR01DK104942 · NIDDK · UNIVERSITY OF CHICAGO · PI GREELEY, SIRI ATMA W., PHILIPSON, LOUIS H. · 2016 to 2024
$4.7M
Neurocognitive Consequences of Intermittent HypoxiaR01NS107421 · NINDS · UNIVERSITY OF CHICAGO · PI GARCIA, ALFREDO J · 2018 to 2022
$2.3M
National Institute of Health R01 NS10742101NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK104942NIDDK NIH HHS R01DK104942NINDS NIH HHS R01 NS107421
6 · The paper itself

Abstract

The gene KCNJ11 encodes Kir6.2 a major subunit of the ATP-sensitive potassium channel (K

Indexed as

AdultBrainCell Culture TechniquesDiabetes MellitusElectrophysiologyFemaleFibroblastsHumansInduced Pluripotent Stem CellsInfant, NewbornInfant, Newborn, DiseasesIn Vitro TechniquesKcnj11 ChannelLeukocytes, MononuclearMicroscopy, ConfocalNerve NetKcnj11 ChannelPotassium Channels, Inwardly Rectifying

Identifiers

PMID34732776
PMCPMC8566525
OpenAlexW3210450415

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.