ArticleNature2021
MC3R links nutritional state to childhood growth and the timing of puberty.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 132 citations in OpenAlex.
- IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence.Clinical obesity · 2026Article
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.Journal of neuroendocrinology · 2026Article
- Recent developments in GPCR signalling in appetite regulation.Bioscience reports · 2026Review
- Neural Melanocortin Receptors in Fish: Insights into Growth Regulation and Aquaculture Advancement.Biomolecules · 2026Review
- Sex-differential associations of MC3R p.F45S with human metabolic profile.Journal of neuroendocrinology · 2026Article
- Hypothalamic obesity.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity.Nature communications · 2026Article
- A Dimer for Dinner: The Impact of GHS-R1a Heterodimerization on Feeding Circuits.Biomolecules · 2026Review
- Convergent evolution of a conserved molecular network underlies parenting and sociality.Nature reviews. Genetics · 2026Review
- Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.Nature genetics · 2026Article
- Effect of a partial loss of function MC3R mutation on MC3R+GHSR-1A heterodimer activity and RNF11 regulation.Journal of endocrinological investigation · 2026Article
- Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons.Cell biochemistry and function · 2026Article
- Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The complex interaction between obesity and puberty and its implications for pubertal timing: a review of recent evidence.Endocrine connections · 2026Review
- Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy.Current issues in molecular biology · 2026Review
- Case Report: rapid progressive puberty in siblings withFrontiers in endocrinology · 2026Article
- The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives.Frontiers in endocrinology · 2026Review
- Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance.Molecular metabolism · 2026Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
41 authors at 11 institutions in 4 countries.
B Y H Lam *MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3638-9025
A Williamson *MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7599-9301
S Finer *Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2684-4653
F R DayMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3789-7651
J A TadrossMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8424-1252
A Gonçalves SoaresMRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
K WadeMRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-3362-6280
P SweeneyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
M N BedenbaughDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.
D T PorterLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8042-3251
A MelvinMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
K L J EllacottInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.
R N LippertDepartment of Neurocircuit Development and Function, German Institute of Human Nutrition, Potsdam, Germany.
S BullerMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
J Rosmaninho-SalgadoMedical Genetics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
G K C DowsettMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
K E RidleyDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Z XuDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
I CiminoMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1397-5408
D RimmingtonMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
K RainbowMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
K DuckettMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
S HolmqvistDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6709-6666
A KhanWolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5189-6906
X DaiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
E G BochukovaBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
Genes & Health Research Team
R C TrembathSchool of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
H C MartinWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0002-4454-9084
A P CollMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
D H RowitchDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0079-0060
N J WarehamMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1422-2993
D A van HeelWolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0637-2265
N TimpsonMRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7141-9189
R B SimerlyDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5840-0152
K K OngMRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4689-7530
R D ConeLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3333-5651
C Langenberg *MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5017-7344
J R B Perry *MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6483-3771
G S Yeo *MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8823-3615
S O'Rahilly *MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0003-2199-4449
University of Cambridge · GBQueen Mary University of London · GBUniversity of Bristol · GBUniversity of Michigan · USVanderbilt University · USGerman Institute of Human Nutrition · DEHospitais da Universidade de Coimbra · PTKing's College London · GBNIHR Cambridge Biomedical Research CentreUniversity of Exeter · GBWellcome Sanger Institute · GB
Funding
Melanocortin Signaling in Feeding BehaviorR01DK070332 · NIDDK · VANDERBILT UNIVERSITY · PI CONE, ROGER D. · 2004 to 2017
$6.1MLeptin and Developmental Programming of Hypothalamic Autonomic OutflowR01DK106476 · NIDDK · VANDERBILT UNIVERSITY · PI SIMERLY, RICHARD B · 2016 to 2024
$3.7MSexually Dimorphic Expression and Function of the Melanocortin-3 ReceptorR01DK126715 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CONE, ROGER D. · 2020 to 2022
$1.0MRole of the Melanocortin-3 Receptor in Regulation of the HPG AxisF32HD105386 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PORTER, DANIELLE TIFFANY · 2021 to 2023
$205kMelanocortin 3 receptor in neural circuits linking reproductive state and metabolismF32DK123879 · NIDDK · VANDERBILT UNIVERSITY · PI BEDENBAUGH, MICHELLE · 2019 to 2022
$197kMC3R inhibition as a strategy to maintain weight loss in obesityK99DK127065 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWEENEY, PATRICK · 2020 to 2021
$182kA role for hypothalamic melanocortin 3 receptors in integrating energy state with reproductive physiologyF32HD095620 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWEENEY, PATRICK · 2018 to 2020
$158kCancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00014/1Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12012/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/N003284/1NICHD NIH HHS F32 HD095620NICHD NIH HHS F32 HD105386NIDDK NIH HHS F32 DK123879NIDDK NIH HHS K99 DK127065NIDDK NIH HHS R01 DK070332NIDDK NIH HHS R01 DK106476NIDDK NIH HHS R01 DK126715Wellcome Trust 210561/Z/18/Z
Abstract
The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development
Indexed as
AdolescentAged, 80 and overAnimalsChildChild DevelopmentEstrous CycleFemaleHomozygoteHumansHypothalamusInsulin-Like Growth Factor IMaleMelanocortinsMenarcheMiceNutritional StatusIGF1 protein, humanInsulin-Like Growth Factor IMC3R protein, humanMc3r protein, mouseMelanocortinsReceptor, Melanocortin, Type 3
Identifiers
What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.