Evidence map›Paper›PMID 34734804›Full record

ArticleeLife2021

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.

Tooba Quidwai, Jiaolong Wang, Emma A Hall, Narcis A Petriman, Weihua Leng, Petra Kiesel, Jonathan N Wells, Laura C Murphy, Margaret A Keighren, Joseph A Marsh and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The intraflagellar transport cycle.Nature reviews. Molecular cell biology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Architecture of intraflagellar transport complexes.Nature structural & molecular biology · 2023
    Article
  18. Article
  19. Article
  20. Ciliogenesis membrane dynamics and organization.Seminars in cell & developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Tooba QuidwaiMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5248-9010
Jiaolong WangDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Emma A HallMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Narcis A PetrimanDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3189-7530
Weihua LengMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Petra KieselMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Jonathan N WellsMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-3700-020X
Laura C MurphyMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Margaret A KeighrenMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Joseph A MarshMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Esben LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-6493-7220
Gaia PiginoMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Pleasantine MillMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5218-134X
Institute of Genetics and Cancer · GBAarhus University · DKMax Planck Institute of Molecular Cell Biology and Genetics · DEHuman Technopole · IT

Funding

Medical Research Council MC_UU_00007/14Medical Research Council MC_UU_12018/26
6 · The paper itself

Abstract

Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of cargo within cilia, but how this cargo is selectively transported to cilia is unclear. WDR35/IFT121 is a component of the IFT-A complex best known for its role in ciliary retrograde transport. In the absence of WDR35, small mutant cilia form but fail to enrich in diverse classes of ciliary membrane proteins. In

Indexed as

AnimalsChlamydomonas reinhardtiiCiliaCytoskeletal ProteinsIntracellular Signaling Peptides and ProteinsMiceProtein BindingProtein TransportCytoskeletal ProteinsIntracellular Signaling Peptides and ProteinsWDR35 protein, mousecell biologychlamydomonas reinhardtiiciliaciliary pocketCLEMcoatomerCOPIcorrelative light and electron microscopyIFTintraflagellar transportmembrane cargosmouseTEMtransmission electron microscopyvesicular traffic

Identifiers

PMID34734804
PMCPMC8754431
OpenAlexW3210702290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.