Evidence map›Paper›PMID 34735579›Full record

ReviewJournal of molecular medicine (Berlin, Germany)2022

Sympathetic nerve-adipocyte interactions in response to acute stress.

Gabryella S P Santos, Alinne C Costa, Caroline C Picoli, Beatriz G S Rocha, Sheu O Sulaiman, Debora C Radicchi, Mauro C X Pinto, Miguel L Batista, Jaime H Amorim, Vasco A C Azevedo and 4 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular medicine (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. New-Onset Sleep Disorders before Cardiac Surgery May Indicate an Increased Risk of Postoperative Atrial Fibrillation.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Gabryella S P SantosDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Alinne C CostaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Caroline C PicoliDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Beatriz G S RochaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Sheu O SulaimanDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Debora C RadicchiDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Mauro C X PintoLaboratory of Neuropharmacology, Federal University of Goiás, Goiânia, GO, Brazil.
Miguel L BatistaLaboratory of Adipose Tissue Biology, University of Mogi das Cruzes, Mogi das Cruzes, SP, Brazil.ORCID http://orcid.org/0000-0001-7022-5131
Jaime H AmorimCenter of Biological Sciences and Health, Federal University of Western Bahia, BA, Barreiras, Brazil.
Vasco A C AzevedoCellular and Molecular Genetics Laboratory, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Rodrigo R ResendeDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Niels O S CâmaraLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, SP, Brazil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. birbrair@icb.ufmg.br.ORCID http://orcid.org/0000-0003-1015-2561
Universidade Federal de Minas Gerais · BRColumbia University Irving Medical Center · USUniversidade de Mogi das Cruzes · BRUniversidade de São Paulo · BRUniversidade Federal de Goiás · BRUniversidade Federal do Oeste da Bahia · BR

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072
6 · The paper itself

Abstract

Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment.

Indexed as

AdipocytesAnimalsHumansInterleukin-6Stress, PsychologicalSympathetic Nervous SystemTumor MicroenvironmentInterleukin-6AdipocytesHepatocytesIL-6MicroenvironmentSympathetic nerves

Identifiers

PMID34735579
PMCPMC8567732
OpenAlexW3208199415

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.