ArticleEnvironment international2022
Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach.
Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Birth weight in relation to maternal and neonatal biomarker concentration of perfluorooctane sulfonic acid: a meta-analysis and meta-regression from a systematic review.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Systematic review and meta-analysis of birth weight and perfluorohexane sulfonate exposures: examination of sample timing and study confidence.Occupational and environmental medicine · 2024Pooled it
- Metabolomic data presents challenges for epidemiological meta-analysis: a case study of childhood body mass index from the ECHO consortium.Metabolomics : Official journal of the Metabolomic Society · 2024Pooled it
- Determinants of maternal and neonatal PFAS concentrations: a review.Environmental health : a global access science source · 2023Pooled it
- Systematic review and meta-analysis of birth weight and PFNA exposures.Environmental research · 2023Pooled it
- Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020.Environmental health perspectives · 2026Article
- Revealing the Link Between Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Stroke: A Comprehensive Epidemiological and Network Toxicology Perspective.Cardiovascular toxicology · 2026Article
- Dietary folate, vitamin D, and inflammation modify associations between prenatal per- and polyfluoroalkyl substance (PFAS) exposures and fetal growth.Nutrition and health · 2026Article
- Integrating omics and artificial intelligence in pediatric environmental health: tools, challenges, and cohort-based insights.Pediatric research · 2026Review
- Untargeted Blubber Metabolomics Reveals Biochemical Signatures Associated with Physiological Status in Live, Free-Ranging Bottlenose Dolphins.Metabolites · 2026Article
- Metabolome-wide association study identifies metabolites associated with human exposure to perfluoroalkyl substances.Journal of exposure science & environmental epidemiology · 2026Article
- Prenatal PFAS Exposure in a Twin Pregnancy Cohort: Associations with Thyroid Disruption, Placental Malperfusion, and Fetal Growth Restriction.Environmental science & technology · 2026Article
- Metabolomics of per- and polyfluoroalkyl substances (PFAS) exposure: Advances in LC-MS technology and applications.Journal of food and drug analysis · 2026Review
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- Per- and polyfluoroalkyl substances serum concentrations during pregnancy and gestational weight gain in the Healthy Start Study.International journal of hygiene and environmental health · 2026Article
- Nontargeted screening identifies mixtures of environmental pollutants that are associated with perturbations to amino acid and fatty acid metabolic pathways during early pregnancy.Environment international · 2026Article
- Evaluating Methods for High-Dimensional Mediation in Metabolomics Data.Environmental science & technology · 2026Article
- The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency.Environment international · 2025Article
- Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort.Science advances · 2025Article
- Maternal serum and placental metabolomes in association with prenatal exposure to per- and polyfluoroalkyl substances and their relevance to child neurodevelopment in an ASD-enriched cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrenatal exposures to per- and polyfluoroalkyl substances (PFAS) have been linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely unknown. This study aims to investigate biological pathways and intermediate biomarkers underlying the association between serum PFAS and fetal growth using high-resolution metabolomics in a cohort of pregnant African American women in the Atlanta area, Georgia.
methodsSerum perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) measurements and untargeted serum metabolomics profiling were conducted in 313 pregnant African American women at 8-14 weeks gestation. Multiple linear regression models were applied to assess the associations of PFAS with birth weight and small-for-gestational age (SGA) birth. A high-resolution metabolomics workflow including metabolome-wide association study, pathway enrichment analysis, and chemical annotation and confirmation with a meet-in-the-middle approach was performed to characterize the biological pathways and intermediate biomarkers of the PFAS-fetal growth relationship.
resultsEach log
conclusionIn this cohort of pregnant African American women, higher serum concentrations of PFOA and PFNA were associated with reduced fetal growth. Perturbations of biological pathways involved in amino acid, lipid and fatty acid, bile acid, and androgenic hormone metabolism were associated with PFAS exposures and reduced fetal growth, and uric acid was shown to be a potential intermediate biomarker. Our results provide opportunities for future studies to develop early detection and intervention for PFAS-induced fetal growth restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.