Evidence map›Paper›PMID 34737756›Full record

ArticleFrontiers in immunology2021

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and Varicella Zoster Virus Infection - Frequency of an Association.

Franziska Di Pauli, Paul Morschewsky, Klaus Berek, Michael Auer, Angelika Bauer, Thomas Berger, Gabriel Bsteh, Paul Rhomberg, Kathrin Schanda, Anne Zinganell and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Franziska Di PauliDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Paul MorschewskyDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Klaus BerekDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Michael AuerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Angelika BauerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Thomas BergerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Gabriel BstehDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Paul RhombergDepartment of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria.
Kathrin SchandaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Anne ZinganellDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Florian DeisenhammerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Markus ReindlDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Harald HegenDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATUniversität Innsbruck · ATMedical University of Vienna · AT

Funding

Austrian Science Fund FWF P 32699
6 · The paper itself

Abstract

To determine whether there is a correlation between myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases and varicella zoster virus (VZV) infection. We provide a case report and performed a study to determine the frequency of MOG antibodies (MOG-IgG) in neurological VZV infections. Patients admitted to the Medical University of Innsbruck from 2008-2020 with a diagnosis of a neurological manifestation of VZV infection (n=59) were included in this study; patients with neuroborreliosis (n=34) served as control group. MOG-IgG was detected using live cell-based assays. In addition, we performed a literature review focusing on MOG and aquaporin-4 (AQP4) antibodies and their association with VZV infection. Our case presented with VZV-associated longitudinally extensive transverse myelitis and had MOG-IgG at a titer of 1:1280. In the study, we did not detect MOG-IgG in any other patient neither in the VZV group (including 15 with VZV encephalitis/myelitis) nor in the neuroborreliosis group. In the review of the literature, 3 cases with MOG-IgG and additional 9 cases with AQP4 IgG associated disorders in association with a VZV infection were identified. MOG-IgG are rarely detected in patients with VZV infections associated with neurological diseases.

Indexed as

AdultAgedAquaporin 4AutoantibodiesEncephalitisFemaleHerpesvirus 3, HumanHumansImmunoglobulin GMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinMyelitis, TransverseRetrospective StudiesReview Literature as TopicVaricella Zoster Virus InfectionAquaporin 4AutoantibodiesImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinAQP-4-IgGlongitudinally extensive transverse myelitisMOG antibody associated diseasesMOG-IgGneuromyelitis optica spectrum disordervaricella zoster virus infection

Identifiers

PMID34737756
PMCPMC8560958
OpenAlexW3207513614

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.