Evidence map›Paper›PMID 34738728›Full record

SynthesisPharmacology research & perspectives2021

Serious adverse drug reactions in sub-Saharan Africa in the era of antiretroviral treatment: A systematic review.

Johannes P Mouton, Nicole Jobanputra, Gayle Tatz, Karen Cohen

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Pharmacology research & perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Johannes P MoutonDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Nicole JobanputraDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Gayle TatzDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Karen CohenDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to summarize and describe the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa (SSA) in the era of antiretroviral therapy. We searched Medline, CINAHL, Africa-Wide Information, Scopus, and Web of Science, without language restriction up to March 2021. We hand-searched reference lists, conference abstracts, and dissertation databases. We included studies reporting proportions of admissions attributed to ADRs, admissions prolonged by ADRs, or in-hospital deaths attributed to ADRs. Two reviewers independently screened the studies, reviewed the study quality using a previously published tool, and extracted the data. We tested for heterogeneity using I

Indexed as

AdultAfrica South of the SaharaAnti-Retroviral AgentsAntitubercular AgentsChildCost of IllnessDrug-Related Side Effects and Adverse ReactionsHospitalizationHumansAnti-Retroviral AgentsAntitubercular Agentsdrug safetymedicine safetypharmacoepidemiologysystematic review

Identifiers

PMID34738728
PMCPMC8569857
OpenAlexW3208514225

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.