Evidence map›Paper›PMID 34739631›Full record

ArticleBiomolecular NMR assignments2022

Backbone

Jeffrey F Ellena, Tuo-Xian Tang, Narasimhamurthy Shanaiah, Daniel G S Capelluto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Phafins Are More Than Phosphoinositide-Binding Proteins.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jeffrey F EllenaBiomolecular Magnetic Resonance Facility, University of Virginia, Charlottesville, VA, 22904, USA.
Tuo-Xian TangProtein Signaling Domains Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, 24061, USA.
Narasimhamurthy ShanaiahDepartment of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Daniel G S CapellutoProtein Signaling Domains Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, 24061, USA. capellut@vt.edu.ORCID 0000-0002-0412-4508
Virginia Tech · USUniversity of Pennsylvania · USUniversity of Virginia · US

Funding

Targeted Small Molecule Inhibitors for Inv(16) LeukemiaR01CA234478 · NCI · UNIVERSITY OF VIRGINIA · PI BUSHWELLER, JOHN HACKETT, CASTILLA, LUCIO H. · 2019 to 2023
$3.4M
800 MHZ NMR SPECTROMETER FOR HIGH-END NMR STRUCTURAL STUDIES: AIDSS10RR023035 · NCRR · UNIVERSITY OF VIRGINIA · PI BUSHWELLER, JOHN HACKETT · 2006 to 2006
$2.0M
Deciphering the Molecular Assembly Mechanism of Giant DNA VirusesR01GM129525 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI XIAO, CHUAN · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA234478NCRR NIH HHS S10 RR023035
6 · The paper itself

Abstract

Phafin2 is a peripheral protein that triggers cellular signaling from endosomal and lysosomal compartments. The specific subcellular localization of Phafin2 is mediated by the presence of a tandem of phosphatidylinositol 3-phosphate (PtdIns3P)-binding domains, the pleckstrin homology (PH) and the Fab-1, YOTB, Vac1, and EEA1 (FYVE) domains. The requirement for both domains for binding to PtdIns3P still remains unclear. To understand the molecular interactions of the Phafin2 PH domain in detail, we report its nearly complete

Indexed as

Pleckstrin Homology DomainsVesicular Transport ProteinsEndosomesNuclear Magnetic Resonance, BiomolecularProtein BindingVesicular Transport ProteinsEndosomeFYVE domainPhafin2PH domainPhosphoinositide

Identifiers

PMID34739631
PMCPMC9068824
OpenAlexW3209165738

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.