Evidence map›Paper›PMID 34739715›Full record

ArticleNeurotoxicity research2021

Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway.

Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Genc

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kemal Ugur TufekciDepartment of Health Care Services, Vocational School of Health Services, Izmir Democracy University, 35290, Izmir, Turkey.ORCID http://orcid.org/0000-0003-0935-1360
Bedir Irem EltutanInternational Biomedicine and Genome Center, Balcova, 35340, Izmir, Turkey.ORCID http://orcid.org/0000-0001-5482-1574
Kamer Burak IsciDepartment of Neuroscience, Health Science Institute, Dokuz Eylul University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-3306-1793
Sermin GencInternational Biomedicine and Genome Center, Balcova, 35340, Izmir, Turkey. sermin.genc@deu.edu.tr.ORCID http://orcid.org/0000-0001-6126-7460
Izmir University · TRDokuz Eylül University · TR

Funding

Dokuz Eylül Üniversitesi 2014.KB.SAG.31
6 · The paper itself

Abstract

Resveratrol is a natural polyphenolic compound with a wide range of biological activities such as antioxidant, anti-carcinogenic, anti-obesity, anti-aging, anti-inflammatory, immunomodulatory properties. Accumulating evidence suggests that resveratrol has pharmacological benefits in life-threatening diseases, including cardiovascular disease, cancer, diabetes, and neurodegenerative diseases. Resveratrol is widely known for its anti-inflammatory properties; however, signaling mechanisms of anti-inflammatory action are still elusive. Studies have illustrated that resveratrol can control different regulatory pathways by altering the expression and consequently regulatory effects of microRNAs. Our study aims to clarify the regulatory mechanisms of resveratrol in its anti-inflammatory features in the N9 microglial cell line. Our results demonstrated that resveratrol inhibits LPS- and ATP-activated NLRP3 inflammasome and protects microglial cells upon oxidative stress, proinflammatory cytokine production, and pyroptotic cell death resulting from inflammasome activation. Additionally, resveratrol inhibits nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and activates AMPK/Sirt1 pathways. Furthermore, our results indicated that resveratrol downregulated inflammasome-induced miR-155 expression. Then, inhibition of AMPK and Sirt1 pathways has significantly reversed protective effect of resveratrol on miR-155 expression. To sum up, our results suggest that resveratrol suppresses the NLRP3 inflammasome and miR-155 expression through AMPK and Sirt1 pathways in microglia.

Indexed as

AMP-Activated Protein KinasesAnimalsBlotting, WesternFluorescent Antibody TechniqueInflammasomesMiceMicrogliaMicroRNAsNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionResveratrolSignal TransductionSirtuin 1AMP-Activated Protein KinasesInflammasomesMicroRNAsMirn155 microRNA, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen SpeciesResveratrolSirt1 protein, mouseSirtuin 1AMPKMicrogliamicroRNANLRP3 inflammasomeResveratrolSirt1

Identifiers

PMID34739715
OpenAlexW3210122352

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.