Evidence map›Paper›PMID 34740719›Full record

ArticleVirus research2022

Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.

Ragothaman Prathiviraj, Paulchamy Chellapandi, Ajima Begum, George Seghal Kiran, Joseph Selvin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ragothaman PrathivirajDepartment of Microbiology, Pondicherry University, Puducherry 605014, India.
Paulchamy ChellapandiDepartment of Bioinformatics, Bharathidasan University, Tiruchirappalli 620024, India.
Ajima BegumNational Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India.
George Seghal KiranDepartment of Food Science and Technology, Pondicherry University, Puducherry 605014, India.
Joseph SelvinDepartment of Microbiology, Pondicherry University, Puducherry 605014, India.
Pondicherry University · INBharathidasan University · INNational Institute of Plant Genome Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The second wave of COVID-19 caused by severe acute respiratory syndrome virus (SARS-CoV-2) is rapidly spreading over the world. Mechanisms behind the flee from current antivirals are still unclear due to the continuous occurrence of SARS-CoV-2 genetic variants. Brazil is the world's second-most COVID-19 affected country. In the present study, we identified the genomic and proteomic variants of Brazilian SARS-CoV-2 isolates. We identified 16 different genotypic variants were found among the 27 isolates. The genotypes of three isolates such as Bra/1236/2021 (G15), Bra/MASP2C844R2/2020 (G11), and Bra/RJ-DCVN5/2020 (G9) have a unique mutant in NSP4 (S184N), 2'O-Mutase (R216N), membrane protein (A2V) and Envelope protein (V5A). A mutation in RdRp of SARS-CoV-2, particularly the change of Pro-to Leu-at 323 resulted in the stabilization of the structure in BRA/CD1739-P4/2020. NSP4, NSP5 protein mutants are more virulent in genotype 15 and 16. A fast protein folding rate changes the structural stability and leads to escape for current antivirals. Thus, our findings help researchers to develop the best potent antivirals based on the new mutant of Brazilian isolates.

Indexed as

Protein FoldingBrazilCoronavirus 3C ProteasesCoronavirus Nucleocapsid ProteinsCoronavirus RNA-Dependent RNA PolymeraseCOVID-19Genetic VariationGenome, ViralHumansPhosphoproteinsSARS-CoV-2Spike Glycoprotein, CoronavirusViral Nonstructural ProteinsVirulence3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesCoronavirus Nucleocapsid ProteinsCoronavirus RNA-Dependent RNA PolymeraseNSP12 protein, SARS-CoV-2nucleocapsid phosphoprotein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Nonstructural ProteinsBrazilian isolatesGenotypic variantsPhylogenomic studyProtein mutationsSARS-CoV-2

Identifiers

PMID34740719
PMCPMC8563081
OpenAlexW3209089121

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.