Evidence map›Paper›PMID 34741024›Full record

ArticleNature communications2021

Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit.

Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere and 5 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Synthetic Biology Meets Machine Learning.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Morgane BooneCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium. morganeboone@gmail.com.ORCID http://orcid.org/0000-0002-7807-5542
Pathmanaban RamasamyCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.ORCID http://orcid.org/0000-0003-4039-5230
Jasper ZuallaertCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Robbin BouwmeesterCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.ORCID http://orcid.org/0000-0001-6807-7029
Berre Van MoerCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.ORCID http://orcid.org/0000-0002-6315-3755
Davy MaddeleinCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Demet TuranCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Niels HulstaertCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Hannah EeckhautCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.ORCID http://orcid.org/0000-0003-1519-3653
Elien VandermarliereCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Lennart MartensCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.ORCID http://orcid.org/0000-0003-4277-658X
Sven DegroeveCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium.
Wesley De NeveCenter for Biotech Data Science, Ghent University Global Campus, Songdo, Incheon, South Korea.ORCID http://orcid.org/0000-0002-8190-3839
Wim VrankenStructural Biology Brussels, VUB, Brussels, Belgium.
Nico CallewaertCenter for Medical Biotechnology, VIB, Zwijnaarde, Belgium. nico.callewaert@vib-ugent.be.ORCID http://orcid.org/0000-0003-2069-6917
Ghent University · BEUniversity College Ghent · BEVIB-VUB Center for Structural Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While transcriptome- and proteome-wide technologies to assess processes in protein biogenesis are now widely available, we still lack global approaches to assay post-ribosomal biogenesis events, in particular those occurring in the eukaryotic secretory system. We here develop a method, SECRiFY, to simultaneously assess the secretability of >10

Indexed as

HumansProteomeSaccharomyces cerevisiaeTranscriptomeProteome

Identifiers

PMID34741024
PMCPMC8571348
OpenAlexW3145492650

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.