Evidence map›Paper›PMID 34743200›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

GABA

Amanda Kiemes, Felipe V Gomes, Diana Cash, Daniela L Uliana, Camilla Simmons, Nisha Singh, Anthony C Vernon, Federico Turkheimer, Cathy Davies, James M Stone and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  2. Article
  3. Article
  4. GABAMolecular psychiatry · 2026
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Amanda KiemesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. amanda.s.kiemes@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6819-8090
Felipe V GomesDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Diana CashDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5021-1234
Daniela L UlianaDepartments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Camilla SimmonsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nisha SinghDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Anthony C VernonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7305-1069
Federico TurkheimerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Cathy DaviesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3011-8643
James M StoneBrighton and Sussex Medical School, University of Sussex, Brighton, UK.ORCID http://orcid.org/0000-0003-3051-0135
Anthony A GraceDepartments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Gemma ModinosDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7870-066X
King's College London · GBUniversity of Pittsburgh · USBrighton and Sussex Medical School · GBUniversidade de São Paulo · BRWarneford Hospital · GB

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
Gating of Information Flow Within the Nucleus AccumbensR37MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRACE, ANTHONY A · 2007 to 2016
$3.3M
Medical Research Council MR/N026063/1NIMH NIH HHS R01 MH057440NIMH NIH HHS R37 MH057440Wellcome TrustWellcome Trust 202397/Z/16/Z
6 · The paper itself

Abstract

Hippocampal hyperactivity driven by GABAergic interneuron deficits and NMDA receptor hypofunction is associated with the hyperdopaminergic state often observed in schizophrenia. Furthermore, previous research in the methylazoxymethanol acetate (MAM) rat model has demonstrated that repeated peripubertal diazepam administration can prevent the emergence of adult hippocampal hyperactivity, dopamine-system hyperactivity, and associated psychosis-relevant behaviors. Here, we sought to characterize hippocampal GABA

Indexed as

Methylazoxymethanol AcetateSchizophreniaAnimalsDisease Models, Animalgamma-Aminobutyric AcidHippocampusRatsReceptors, N-Methyl-D-Aspartategamma-Aminobutyric AcidMethylazoxymethanol AcetateReceptors, N-Methyl-D-Aspartate

Identifiers

PMID34743200
PMCPMC8782908
OpenAlexW3212558380

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.