Evidence map›Paper›PMID 34743271›Full record

ArticleMolecular biology reports2021

Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.

Yu Chen, Shanshan Li, Zhaoxia Xu, Yanyan Zhang, Huirong Zhang, Lijun Shi

Abstract read
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In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu Chen *Department of Exercise Physiology, Beijing Sport University, Beijing, 100084, China.
Shanshan Li *Department of Exercise Physiology, Beijing Sport University, Beijing, 100084, China.
Zhaoxia XuDepartment of Exercise Physiology, Beijing Sport University, Beijing, 100084, China.
Yanyan ZhangDepartment of Exercise Physiology, Beijing Sport University, Beijing, 100084, China.
Huirong ZhangDepartment of Exercise Physiology, Beijing Sport University, Beijing, 100084, China.
Lijun ShiDepartment of Exercise Physiology, Beijing Sport University, Beijing, 100084, China. shilj@bsu.edu.cn.ORCID http://orcid.org/0000-0001-6655-2949
Beijing Sport University · CN

Funding

chinese universities scientific fund 2020049national natural science foundation of china 31771312national natural science foundation of china 32071174
6 · The paper itself

Abstract

backgroundThe imbalance of vasoconstrictor and vasodilator axes of the renin-angiotensin system (RAS) is observed in hypertension. Exercise regulates RAS level and improves vascular function. This study focused on the contribution of RAS axes in vascular function of mesenteric arteries and exercise-induced DNA methylation of the Agtr1a (AT

methodsSpontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats were randomized into exercise or sedentary group. Levels of plasma RAS components, vascular tone, and DNA methylation markers were measured.

resultsBlood pressure of SHR was markedly reduced after 12 weeks of aerobic exercise. RAS peptides in plasma were all increased with an imbalanced upregulation of Ang II and Ang-(1-7) in SHR, exercise revised the level of RAS and increased Ang-(1-7)/Ang II. The vasoconstriction response induced by Ang II was mainly via type 1 receptors (AT

conclusionsAerobic exercise ameliorates vascular function via hypermethylation of the Agtr1a and Mas1 genes and restores the vasoconstrictor and vasodilator axes balance.

Indexed as

Angiotensin IIAnimalsArteriesBlood PressureDNADNA MethylationEpigenesis, GeneticHypertensionMaleMesenteric ArteriesNitric OxidePhysical Conditioning, AnimalPhysical ExertionProto-Oncogene MasPulmonary Arterial HypertensionRatsAgtr1a protein, ratAngiotensin IIDNAMas1 protein, ratNitric OxideProto-Oncogene MasReceptor, Angiotensin, Type 1Vasodilator AgentsAerobic exerciseDNA methylationHypertensionRAS

Identifiers

PMID34743271
OpenAlexW3214126240

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.