Evidence map›Paper›PMID 34745014›Full record

ArticleFrontiers in endocrinology2021

Mélanie C Faure, Rita Khoueiry, Jusal Quanico, Hervé Acloque, Marie-Justine Guerquin, Michael J Bertoldo, Claire Chevaleyre, Christelle Ramé, Isabelle Fournier, Michel Salzet and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  9. Commentary:Frontiers in endocrinology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Mélanie C Faurel'Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), UMR85 Physiologie de la Reproduction et des Comportements/Centre national de la Recherche Scientifique (CNRS), UMR7247/Université François Rabelais de Tours/Institut français du Cheval et de l'Équitation (IFCE), Nouzilly, France.
Rita KhoueiryEpigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France.
Jusal QuanicoUniversité Lille 1, INSERM U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse (PRISM), Villeneuve d'Ascq, France.
Hervé AcloqueUniversité Paris-Saclay, INRAE, AgroParisTech, Génétique Animale et Biologie Intégrative (GABI), Jouy-en-Josas, France.
Marie-Justine GuerquinUMR967 INSERM, Commissariat à l'Énergie Atomique (CEA)/Direction de la Recherche Fondamentale (DRF)/Institut de Radiobiologie Cellulaire et Moléculaire (iRCM)/Service Cellules Souches et Radiation (SCSR)/LDG, Université Paris Diderot, Sorbonne Paris Cité, Université Paris-Sud, Université Paris-Saclay, Laboratory of Development of the Gonads, Fontenay aux Roses, France.
Michael J BertoldoFertility and Research Centre, School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
Claire Chevaleyrel'Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), UMR85 Physiologie de la Reproduction et des Comportements/Centre national de la Recherche Scientifique (CNRS), UMR7247/Université François Rabelais de Tours/Institut français du Cheval et de l'Équitation (IFCE), Nouzilly, France.
Christelle Ramél'Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), UMR85 Physiologie de la Reproduction et des Comportements/Centre national de la Recherche Scientifique (CNRS), UMR7247/Université François Rabelais de Tours/Institut français du Cheval et de l'Équitation (IFCE), Nouzilly, France.
Isabelle FournierUniversité Lille 1, INSERM U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse (PRISM), Villeneuve d'Ascq, France.
Michel SalzetUniversité Lille 1, INSERM U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse (PRISM), Villeneuve d'Ascq, France.
Joëlle Dupontl'Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), UMR85 Physiologie de la Reproduction et des Comportements/Centre national de la Recherche Scientifique (CNRS), UMR7247/Université François Rabelais de Tours/Institut français du Cheval et de l'Équitation (IFCE), Nouzilly, France.
Pascal Fromentl'Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), UMR85 Physiologie de la Reproduction et des Comportements/Centre national de la Recherche Scientifique (CNRS), UMR7247/Université François Rabelais de Tours/Institut français du Cheval et de l'Équitation (IFCE), Nouzilly, France.
Physiologie de la Reproduction et des Comportements · FRUniversité de Lille · FRAgroParisTech · FRCentre international de recherche sur le cancer · FRUniversité Paris-Sud · FRUNSW Sydney · AU

Funding

World Health Organization 001
6 · The paper itself

Abstract

Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance. Metformin is also used in the treatment of pregnancy disorders such as gestational diabetes. However, the consequences of foetal exposure to metformin on the fertility of exposed offspring remain poorly documented. In this study, we investigated the effect of

Indexed as

AnimalsDNA-Binding ProteinsDNA DamageDNA MethylationFemaleHypoglycemic AgentsInfertility, MaleMaleMetforminMiceMice, Inbred C57BLPregnancyPrenatal Exposure Delayed EffectsProto-Oncogene ProteinsSpermatozoaSperm CountDNA-Binding ProteinsHypoglycemic AgentsMetforminProto-Oncogene ProteinsTET1 protein, mouseembryometforminovarypregnancyspermatozoatestis

Identifiers

PMID34745014
PMCPMC8565088
OpenAlexW3207314349

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.