Evidence map›Paper›PMID 34745305›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

GuanXinNing Tablet Attenuates Alzheimer's Disease via Improving Gut Microbiota, Host Metabolites, and Neuronal Apoptosis in Rabbits.

Feng Zhang, Yanyun Xu, Liye Shen, Junjie Huang, Songtao Xu, Jiaying Li, Zhichao Sun, Jiangmin He, Minli Chen, Yongming Pan

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Frontiers in pharmacology · 2025
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  14. Frontiers in cardiovascular medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Feng ZhangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID https://orcid.org/0000-0003-2887-1505
Yanyun XuInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Liye ShenInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Junjie HuangInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Songtao XuInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jiaying LiThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhichao SunThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jiangmin HeChiatai Qingchunbao Pharmaceutical Co., Ltd., Hangzhou 310023, China.ORCID https://orcid.org/0000-0003-0257-0210
Minli ChenInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID https://orcid.org/0000-0003-1911-9397
Yongming PanInstitute of Comparative Medicine, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID https://orcid.org/0000-0001-8085-9760
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on accumulating evidence, Alzheimer's disease (AD) is related to hypercholesterolemia, gut microbiota, and host metabolites. GuanXinNing Tablet (GXN) is an oral compound preparation composed of two Chinese herbs,

Identifiers

PMID34745305
PMCPMC8568547
OpenAlexW3208074387

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.