Evidence map›Paper›PMID 34749671›Full record

ReviewBMC medical imaging2021

Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques.

Vasiliki Tsampasian, Andrew J Swift, Hosamadin Assadi, Amrit Chowdhary, Peter Swoboda, Eva Sammut, Amardeep Dastidar, Jordi Broncano Cabrero, Javier Royuela Del Val, Sunil Nair and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in BMC medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Phosphorus Magnetic Resonance Spectroscopy (Medicina (Kaunas, Lithuania) · 2023
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Imaging of Thromboinflammation by MultispectralInternational journal of molecular sciences · 2025
    Review
  7. Review
  8. Diastolic function in chronic kidney disease.Clinical kidney journal · 2023
    Review
  9. Review
  10. Review
  11. Imaging Methods: Magnetic Resonance Imaging.Circulation. Cardiovascular imaging · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Vasiliki TsampasianNorwich Medical School, University of East Anglia, Norwich, UK.
Andrew J SwiftDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Hosamadin AssadiDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Amrit ChowdharyLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Peter SwobodaLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Eva SammutUniversity of Bristol, Bristol, UK.
Amardeep DastidarUniversity of Bristol, Bristol, UK.
Jordi Broncano CabreroCardiothoracic Imaging Unit, Hospital San Juan de Dios, Ressalta, HT Medica, Cordoba, Spain.
Javier Royuela Del ValCardiothoracic Imaging Unit, Hospital San Juan de Dios, Ressalta, HT Medica, Cordoba, Spain.
Sunil NairNorfolk and Norwich University Hospital, Norwich, UK.
Robin NijveldtCardiology Department, Radboudumc, Nijmegen, The Netherlands.
Alisdair RydingNorfolk and Norwich University Hospital, Norwich, UK.
Chris SawhNorfolk and Norwich University Hospital, Norwich, UK.
Chiara Bucciarelli-DucciUniversity of Bristol, Bristol, UK.
Eylem LeveltLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Vassilios VassiliouNorwich Medical School, University of East Anglia, Norwich, UK.
Pankaj GargNorwich Medical School, University of East Anglia, Norwich, UK. p.garg@sheffield.ac.uk.ORCID 0000-0002-5483-169X
Norfolk and Norwich University Hospital · GBUniversity of Bristol · GBUniversity of East Anglia · GBUniversity of Leeds · GBUniversity of Sheffield · GBRadboud University Nijmegen · NL

Funding

Wellcome Trust 205188/Z/16/ZWellcome Trust (GB) 215799/Z/19/Z
6 · The paper itself

Abstract

The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance has been a powerful tool in the non-invasive assessment of inflammation in several conditions. More recently, Ultrasmall superparamagnetic particles of iron oxide have been successfully used to evaluate macrophage activity and subsequently inflammation on a cellular level. Current evidence from research studies provides encouraging data and confirms that this evolving method can potentially have a huge impact on clinical practice as it can be used in the diagnosis and management of very common conditions such as coronary artery disease, ischaemic and non-ischaemic cardiomyopathy, myocarditis and atherosclerosis. Another important emerging concept is that of myocardial energetics. With the use of phosphorus magnetic resonance spectroscopy, myocardial energetic compromise has been proved to be an important feature in the pathophysiological process of several conditions including diabetic cardiomyopathy, inherited cardiomyopathies, valvular heart disease and cardiac transplant rejection. This unique tool is therefore being utilized to assess metabolic alterations in a wide range of cardiovascular diseases. This review systematically examines these state-of-the-art methods in detail and provides an insight into the mechanisms of action and the clinical implications of their use.

Indexed as

Cardiovascular DiseasesContrast MediaFerric CompoundsHumansInflammationMagnetic Resonance ImagingMagnetic Resonance SpectroscopyContrast MediaFerric Compoundsferric oxideCardiovascular magnetic resonance (CMR)Magnetic resonance spectroscopy (MRS)Ultrasmall superparamagnetic particles of iron oxide (USPIO)

Identifiers

PMID34749671
PMCPMC8573867
OpenAlexW3213995865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.