ArticleIntensive care medicine2021
Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study.
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00512122 (Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness.Intensive care medicine · 2025Trial
- Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review.Intensive care medicine · 2026Review
- Observational
- Muscle Dysfunction and Physical Recovery After Critical Illness.Journal of intensive care medicine · 2026Review
- Translation and cross-cultural adaption of the German version of the Intensive Care Unit Mobility Scale (IMS).Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Post-intensive care syndrome: a state-of-the-art review.Singapore medical journal · 2026Review
- Functional and muscle recovery after critical illness: current and future nutritional, physical and metabolic strategies.Annals of intensive care · 2026Review
- Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles.Critical care (London, England) · 2025Review
- Exploring Peripheral and Respiratory Muscle Weakness and Functional Impairments in ICU Patients: Insights From a Resource-Constrained Setting.Critical care explorations · 2025Observational
- Survivorship After Cardiogenic Shock.Circulation · 2025Review
- Post-Intensive Care Syndrome as a Burden for Patients and Their Caregivers: A Narrative Review.Journal of clinical medicine · 2024Review
- Identifying limitations to exercise with incremental cardiopulmonary exercise testing: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Hemodynamic Melody of Postnatal Cardiac and Pulmonary Development in Children with Congenital Heart Diseases.Biology · 2024Review
- Physical function measures in ICU survivors, where to now? A scoping review.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.Critical care (London, England) · 2023Review
- Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- Sex-differences in the longitudinal recovery of neuromuscular function in COVID-19 associated acute respiratory distress syndrome survivors.Frontiers in medicine · 2023Article
- Long-term comprehensive cardiopulmonary phenotyping of COVID-19.Respiratory research · 2022Article
- Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest.Resuscitation plus · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate aerobic exercise capacity in 5-year intensive care unit (ICU) survivors and to assess the association between severity of organ failure in ICU and exercise capacity up to 5-year follow-up.
methodsSecondary analysis of the EPaNIC follow-up cohort (NCT00512122) including 433 patients screened with cardiopulmonary exercise testing (CPET) between 1 and 5 years following ICU admission. Exercise capacity in 5-year ICU survivors (N = 361) was referenced to a historic sedentary population and further compared to demographically matched controls (N = 49). In 5-year ICU survivors performing a maximal CPET (respiratory exchange ratio > 1.05, N = 313), abnormal exercise capacity was defined as peak oxygen consumption (VO
resultsExercise capacity was abnormal in 118/313 (37.7%) 5-year survivors versus 1/48 (2.1%) controls with a maximal CPET, p < 0.001. Aerobic exercise capacity was lower in 5-year survivors than in controls (VO
conclusionsCritical illness survivors often display abnormal aerobic exercise capacity, frequently involving muscular limitation. Severity of organ failure throughout the ICU stay independently associates with these impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.