Evidence map›Paper›PMID 34751615›Full record

ArticleRadiology2022

Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI: Correlation with Histologic Findings.

Aritrick Chatterjee, Crystal Mercado, Roger M Bourne, Ambereen Yousuf, Brittany Hess, Tatjana Antic, Scott Eggener, Aytekin Oto, Gregory S Karczmar

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Quantitative Prostate MRI, From theAJR. American journal of roentgenology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. MRI-based virtual pathology of the prostate.Magma (New York, N.Y.) · 2024
    Review
  17. Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Aritrick ChatterjeeFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0003-4022-7106
Crystal MercadoFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0003-2547-5160
Roger M BourneFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0003-2755-089X
Ambereen YousufFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0002-0475-9087
Brittany HessFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0003-1529-3208
Tatjana AnticFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0002-0455-9413
Scott EggenerFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).
Aytekin OtoFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).ORCID 0000-0003-4325-2489
Gregory S KarczmarFrom the Department of Radiology (A.C., C.M., A.Y., A.O., G.S.K.), Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy (A.C., A.Y., A.O., G.S.K.), Human Tissue Resource Center (B.H.), Department of Pathology (T.A.), and Section of Urology, Department of Surgery (S.E.), University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637; and Discipline of Medical Imaging Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (R.M.B.).
University of Chicago · USThe University of Sydney · AU

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Detection of prostate Cancer Specific Signals with Hybrid Multi-Dimensional MRIR01CA228036 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., OTO, AYTEKIN · 2019 to 2023
$2.7M
Quantitative DCEMRI of Prostate Cancer Correlation with Gold StandardsR01CA172801 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., OTO, AYTEKIN · 2013 to 2017
$2.3M
3T MRI Scanner for multidisciplinary imaging and image-guided therapyS10OD018448 · OD · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S. · 2014 to 2014
$2.0M
MR Virtual Pathology of the ProstateR41CA244056 · NCI · QMIS, LLC · PI KARCZMAR, GREGORY S., MUSTAFI, DEVKUMAR · 2020 to 2020
$225k
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA172801NCI NIH HHS R01 CA228036NCI NIH HHS R41 CA244056NIH HHS S10 OD018448
6 · The paper itself

Abstract

Background Tissue estimates obtained by using microstructure imaging techniques, such as hybrid multidimensional (HM) MRI, may improve prostate cancer diagnosis but require histologic validation. Purpose To validate prostate tissue composition measured by using HM MRI, with quantitative histologic evaluation from whole-mount prostatectomy as the reference standard. Materials and Methods In this HIPAA-compliant study, from December 2016 to July 2018, prospective participants with biopsy-confirmed prostate cancer underwent 3-T MRI before radical prostatectomy. Axial HM MRI was performed with all combinations of echo times (57, 70, 150, and 200 msec) and

Indexed as

Diagnosis, DifferentialHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesProstateProstatectomyProstatic Neoplasms

Identifiers

PMID34751615
PMCPMC8805656
OpenAlexW3212770144

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.