Evidence map›Paper›PMID 34756026›Full record

ArticleJournal of medicinal chemistry2021

Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising

Fabrice G Siméon, Jae-Hoon Lee, Cheryl L Morse, Ian Stukes, Sami S Zoghbi, Lester S Manly, Jeih-San Liow, Robert L Gladding, Rachel M Dick, Xuefeng Yan and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. TSPO Radioligands for Neuroinflammation: An Overview.Molecules (Basel, Switzerland) · 2024
    Review
  4. Review
  5. In vivo evaluation of a novelEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  6. Review
  7. Chem · 2023
    Article
  8. Pharmaceutics · 2022
    Review
  9. Review
  10. In Vivo Evaluation of 6 Analogs ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Fabrice G SiméonMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Jae-Hoon LeeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-9898-9886
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ian StukesMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Lester S ManlyMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Robert L GladdingMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Rachel M DickMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Xuefeng YanMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Sabrina TalianiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-8675-939X
Barbara CostaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7598-1275
Claudia MartiniDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-9379-3027
Federico Da SettimoDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7897-7917
Sabrina CastellanoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.ORCID 0000-0002-7449-3704
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0001-9032-2553
National Institutes of Health · USUniversity of Pisa · ITUniversity of Salerno · IT

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
PET Radiopharmaceutical SciencesZ01MH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2002 to 2008
$7.4M
Preclinical Evaluation Of PET RadiotracersZ01MH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2002 to 2008
$3.2M
Using Computation to Achieve Breakthroughs in NeuroscienceT32MH115886 · NIMH · UNIVERSITY OF MINNESOTA · PI REDISH, A DAVID · 2018 to 2022
$1.7M
Intramural NIH HHS Z01 MH002793Intramural NIH HHS Z01 MH002795Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NIMH NIH HHS T32 MH115886
6 · The paper itself

Abstract

Translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation. [

Indexed as

Positron-Emission TomographyAnimalsBrainCarbon RadioisotopesFluorineHumansLigandsMiceRadiopharmaceuticalsReceptors, GABABzrp protein, mouseCarbon RadioisotopesFluorineLigandsRadiopharmaceuticalsReceptors, GABA

Identifiers

PMID34756026
PMCPMC8817670
OpenAlexW3212964539

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.