Evidence map›Paper›PMID 34757597›Full record

ArticleMolecular biology reports2022

Association of ACE I/D gene polymorphism and related risk factors in impaired fasting glucose and type 2 diabetes: a study among two tribal populations of North-East India.

Sunanda Rajkumari, Somorjit Singh Ningombam, Varhlun Chhungi, Masan Kambo Newmei, Naorem Kiranmala Devi, Prakash Ranjan Mondal, Kallur Nava Saraswathy

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sunanda RajkumariLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Somorjit Singh NingombamLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Varhlun ChhungiLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Masan Kambo NewmeiLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Naorem Kiranmala DeviLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Prakash Ranjan MondalLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India.
Kallur Nava SaraswathyLaboratory of Biochemical and Molecular Anthropology, Department of Anthropology, University of Delhi, New Delhi, 110007, India. knsaraswathy@yahoo.com.ORCID http://orcid.org/0000-0002-0826-9675

Funding

r&d, university of delhi Development Grant 2014-15 RC/2014/r&d, university of delhi Research
6 · The paper itself

Abstract

backgroundType 2 diabetes is a serious public health concern in India, even the indigenous tribal populations are not left unaffected. The present study aims to understand the association of major risk factors i.e. obesity, hypertension, dyslipidemia, ACE I/D polymorphism with impaired fasting glucose (IFG) and type 2 diabetes (T2D) among two different Mendelian populations of North East India.

methodsDemographic, somatometric, physiological variables along with fasting blood samples were collected from 609 individuals. The participants were screened for ACE I/D polymorphism.

resultsACE I/D polymorphism was found to follow HWE among Liangmai tribe but not among Mizo tribe. Distribution of DD genotype/D allele was found to be significantly higher for T2D among Mizo tribe. Significant association were observed between DD genotype/D allele of ACE I/D polymorphism and TC as well as LDL with both IFG and T2D only in Mizo tribe.

conclusionsThe present study is an example of gene-environment interaction where DD genotype or D allele and dyslipidemia (high TC and high LDL) are posing risk for IFG and T2D both independently and in combination only among Mizo tribe with relatively less physical activity attributed to their residence in less hilly terrain however Liangmai tribe which resides in high hilly terrain shows no such association.

Indexed as

AdultAllelesAngiotensin-Converting Enzyme 2Asian PeopleBody Mass IndexDiabetes Mellitus, Type 2DyslipidemiasEthnicityFastingFemaleGenotypeGlucoseHumansHypertensionINDEL MutationIndiaAngiotensin-Converting Enzyme 2GlucosePeptidyl-Dipeptidase AACE I/D polymorphismDyslipidemiaGene-environment interactionImpaired fasting glucoseTribal populationType 2 diabetes

Identifiers

PMID34757597

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.