Evidence map›Paper›PMID 34758303›Full record

ArticleCell reports2021

Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes.

Kunwei Wu, David Castellano, Qingjun Tian, Wei Lu

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Astrocytic Zinc Transporter ZIP12 Is a Synaptic Protein That Contributes to Synaptic Zinc Levels in the Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Review
  8. Article
  9. Haploinsufficiency of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kunwei WuSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
David CastellanoSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Qingjun TianSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Wei LuSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luw4@mail.nih.gov.
National Institutes of Health · US

Funding

The regulation of synaptic transmission and neural circuit functionZIANS003136 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LU, WEI · 2012 to 2025
$27.0M
Intramural NIH HHS ZIA NS003136
6 · The paper itself

Abstract

Tonic inhibition mediated by extrasynaptic GABA

Indexed as

Neural InhibitionAnimalsExcitatory Amino Acid AgonistsGABAergic NeuronsHippocampusKainic AcidMaleMiceProtein TransportReceptors, N-Methyl-D-AspartateSeizuresSignal TransductionSynapsesExcitatory Amino Acid AgonistsKainic AcidNR2B NMDA receptorReceptors, N-Methyl-D-AspartateEpilepsyGABA(A) receptor traffickingGABAergic transmissionGluN2 subunit compositionHomeostatic plasticityNMDA receptor functionSeizureSynaptic plasticityTonic inhibitionα5-GABA(A) receptor

Identifiers

PMID34758303
PMCPMC8630577
OpenAlexW3207524547

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.